Darragh Duffy leads the Translational Immunology unit at the Institut Pasteur, Paris and is co-coordinator of the LabEx Milieu Interieur project. The overall goal of his research is to better understand the fundamental mechanisms behind inter-individual differences in immune responses, and apply these discoveries to relevant clinical questions. To do this they use cellular mechanistic models, population immunology cohorts, and experimental clinical studies in infection and autoimmunity. They work closely with clinical collaborators with the goal that the research findings will help to develop new patient management strategies. For fundamental questions related to understanding immune variability they apply systems immunology approaches to diverse phenotypes and integrate with genetic and environmental factors.
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Courses
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
2018-12-02 09:00:00
2018-12-15 18:00:00
Europe/Paris
10th HKU-Pasteur Immunology Course: December 2-15, 2018
‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
HKU-Pasteur Research Centre, Hong Kong
Transversal Projects
Projects
Former Teams
Publications
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2024Systems vaccinology studies – achievements and future potential., Microbes Infect 2024 Mar; (): 105318.
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2024Smoking changes adaptive immunity with persistent effects., Nature 2024 Feb; 626(8000): 827-835.
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2024VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation., Nat Commun 2024 Jan; 15(1): 910.
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2023Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response., Gut Microbes 2023 Dec; 15(2): 2287618.
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2023Neutralizing antibody levels as a correlate of protection against SARS-CoV-2 infection: a modeling analysis., Clin Pharmacol Ther 2023 Oct; (): .
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2023Dissecting human population variation in single-cell responses to SARS-CoV-2, Nature, 2023, 53 (8), pp.e2250307. ⟨10.1038/s41586-023-06422-9⟩.
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2023Heterogeneity and functions of the 13 IFN-α subtypes – lucky for some?, Eur J Immunol 2023 Aug; 53(8): e2250307.
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2023T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations, Frontiers in Immunology, 2023, 14, pp.1163466. ⟨10.3389/fimmu.2023.1163466⟩.
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2023Successful treatment of JAK1-associated inflammatory disease., J Allergy Clin Immunol 2023 Jun; (): .
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2023JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study., J Clin Immunol 2023 May; (): 1-12.
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