Networks and Signaling

Présentation

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Membres

Thierry Rose

Chercheur(euse) Permanent(e)

Responsable

Pascal Bochet

Sophie Goyard

Projets

project

ongoing

3 Membres

Application of IL7-signaling research to guide diagnostic and therapeutic strategies

Thierry Rose (PI)

When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the […]

project

ongoing

3 Membres

Basic Research – IL7 signaling in T-cells

Thierry Rose (PI)

With the technological support of facilities at the Pasteur Institute and through collaborations with several international institutions, we study the early steps of signaling induced by interleukin-7 on CD4 T lymphocytes (helper). This cytokine […]

Projet Transversal

Biologie quantitative

Le programme de biologie quantitative de l’Institut Pasteur est destiné à faciliter la recherche et l’éducation à l’interface entre la biologie et les sciences plus quantitatives. L’un des principaux objectifs de la biologie quantitative […]

Publications

Télécharger

• 2013
  Tamarit B, Bugault F, Pillet AH, Lavergne V, Bochet P, Garin N, Schwarz U, Thèze J, Rose T, Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells, J. Biol. Chem. 2013 Mar;288(12):8691-701.
• 2011
  Pillet AH, Thèze J, Rose T, Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes, Hum. Immunol. 2011 Nov;72(11):1013-7.
• 2010
  Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G, KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain, J. Biol. Chem. 2011 Jan;286(1):707-16.
• 2010
  Pillet AH, Lavergne V, Pasquier V, Gesbert F, Thèze J, Rose T, IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork, J. Mol. Biol. 2010 Nov;403(5):671-92.
• 2010
  Graille M, Pagano M, Rose T, Ravaux MR, van Tilbeurgh H, Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding, Structure 2010 Jun;18(6):710-8.
• 2010
  Pouget E, Fay N, Dujardin E, Jamin N, Berthault P, Perrin L, Pandit A, Rose T, Valéry C, Thomas D, Paternostre M, Artzner F, Elucidation of the self-assembly pathway of lanreotide octapeptide into beta-sheet nanotubes: role of two stable intermediates, J. Am. Chem. Soc. 2010 Mar;132(12):4230-41.
• 2010
  Rose T, Pillet AH, Lavergne V, Tamarit B, Lenormand P, Rousselle JC, Namane A, Thèze J, Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response, J. Biol. Chem. 2010 May;285(20):14898-908.
• 2009
  Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH, Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients, J. Immunol. 2009 Jun;182(12):7389-97.
• 2009
  Pillet AH, Bugault F, Thèze J, Chakrabarti LA, Rose T, A programmed switch from IL-15- to IL-2-dependent activation in human NK cells, J. Immunol. 2009 May;182(10):6267-77.
• 2009
  Bannwarth L, Rose T, Dufau L, Vanderesse R, Dumond J, Jamart-Grégoire B, Pannecouque C, De Clercq E, Reboud-Ravaux M, Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases, Biochemistry 2009 Jan;48(2):379-87.
• +
  Voir la liste complète de publications

Contact

rose@pasteur.fr

Networks and Signaling – CITech
Roux building 1st floor, room 14
25-28 Rue du Docteur Roux
75015, Paris
France

Publié le: 17 Feb 2015 • Modifié le: 17 Sep 2015