Notre laboratoire s’intéresse aux mécanismes moléculaires qui régissent la forme et la taille des bactéries. A l’aide de dispositifs micro-fluidiques, de microscopie à l’échelle unicellulaire et d’imagerie computationnelle, nous voulons comprendre comment une bactérie régule son volume, sa taille et sa forme en fonction de la disponibilité des nutriments présents dans son milieu de culture. Comprendre ces mécanismes est essentiel pour pouvoir développer de nouveaux agents antimicrobiens.
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Connexions
Membres
Sven Van Teeffelen
Responsable de Structure
Responsable
Anciens Membres
Emplois
Projets
Projet Transversal
Financements
Publications
Télécharger-
2020Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects, eLife 2020;9:e51998.
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2019Bacteria control cell volume by coupling cell-surface expansion to dry-mass growth, biorRxiv 2019; 769786.
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2019Transpeptidase PBP2 governs initial localization and activity of major cell-wall synthesis machinery in Escherichia coli, BioRxiv (2019) 716407. doi:10.1101/716407..
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2019Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems, Nat Microbiol 2019 May;.
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2018Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes, Molecular Systems Biology (2018) 14, e7899.
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2018Recent advances in understanding how rod-like bacteria stably maintain their cell shapes, F1000Research 2018, 7(F1000 Faculty Rev):241.
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2017Mechanical strain-sensing implicated in cell shape recovery in Escherichia coli, Nat. Microbio. 2017; 2:17115.
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2016Architectural transitions in Vibrio cholerae biofilms at single-cell resolution, Proc. Natl. Acad. Sci. U.S.A. 2016 Mar; 113(14): E2066-72.
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2015Private: Differential interaction forces govern bacterial sorting in early biofilms, Elife 2015;4.
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2015Private: Gene Transfer Efficiency in Gonococcal Biofilms: Role of Biofilm Age, Architecture, and Pilin Antigenic Variation, J. Bacteriol. 2015 Jul;197(14):2422-31.
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Lab News
April 2016 – Akshay and Gizem will join the lab as PhD students starting in the fall 2016. Welcome!
March 2016 – Eva receives a “PRESTIGE” postdoctoral fellowship. Congratulations!
March 2016 – Hélène and Irida join as a M2 students. Hélène works on protein-protein interactions using correlation spectroscopy. Irida will use biochemistry and genetics to study the cell-wall expansion machinery. Welcome!
February 2016 – Louis and Thomas from the interdisciplinary AIV master program join the lab for their master thesis projects. Welcome!
October 19 2015 – Sven receives an Emergences grant from the City of Paris.
October 12 2015 – After an excursion to the iGEM competition Antoine returns for his PhD under joint supervision in the Synthetic biology lab and in our lab. Welcome back!
October 9 2015 – Sven receives ERC starting grant!
October 1 2015 – Together with Paolo Pierobon, Jeanette Nguyen, and Chiara Fracassi, Sven teaches a course on the Dynamics of Living Systems within the Master program of the Centre de Recherche Interdisciplinaire.
Lab pictures
Contact
Sven van Teeffelen
email: sven_at_pasteur_dot_fr
phone : +33 (0)1 45 68 80 16
Florence Dumonteil (assistante)
phone : +33 (0)1 45 68 87 99
Address:
Institut Pasteur
Laboratory of Microbial Morphogenesis and Growth
Bâtiment 26 François Jacob (2e étage)
28, rue du Docteur Roux
75724 Paris Cedex 15