Notre laboratoire s’intéresse aux mécanismes moléculaires qui régissent la forme et la taille des bactéries. A l’aide de dispositifs micro-fluidiques, de microscopie à l’échelle unicellulaire et d’imagerie computationnelle, nous voulons comprendre comment une bactérie régule son volume, sa taille et sa forme en fonction de la disponibilité des nutriments présents dans son milieu de culture. Comprendre ces mécanismes est essentiel pour pouvoir développer de nouveaux agents antimicrobiens.
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Connexions
Membres
Sven Van Teeffelen
Responsable de Structure
Responsable
Anciens Membres
2000
2000
Name
Position
2015
2020
Noémie Berenger-Currias
Undergraduate Student
2015
2020
Ewen Corre
Post-doc
2015
2020
Manish Nepal
Post-doc
2015
2020
Athanasios Tsagkadouras
Undergraduate Student
2015
2020
Ann-Kathrin Wagner
Undergraduate Student
2015
2020
Thomas Meiller-Legrand
Undergraduate Student
2015
2020
Louis Faure
Undergraduate Student
2015
2020
Hélène Vignes
Undergraduate Student
2015
2020
Gökberk Alagoz
Undergraduate Student
2015
2020
Irida Goxhaj
Undergraduate Student
2015
2020
Elisa Brambilla
Post-doc
2015
2020
Efthymia Lioliou
Post-doc
2015
2020
Nitai Steinberg
PhD Student
2015
2020
Leonie Carmen Vollmar
Undergraduate Student
2015
2020
Lorenzo Baldi
Undergraduate Student
2015
2020
Michael Szabo
Undergraduate Student
2015
2020
Eric Rouvière
Undergraduate Student
2015
2020
Eva Wollrab
Post-doc
2015
2020
Florence Dumonteil
Administrative Staff
2015
2020
Corinne Billion
Administrative Staff
Emplois
Projets
Projet Transversal
Financements
Publications
Télécharger-
2020Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects, eLife 2020;9:e51998.
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2019Bacteria control cell volume by coupling cell-surface expansion to dry-mass growth, biorRxiv 2019; 769786.
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2019Transpeptidase PBP2 governs initial localization and activity of major cell-wall synthesis machinery in Escherichia coli, BioRxiv (2019) 716407. doi:10.1101/716407..
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2019Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems, Nat Microbiol 2019 May;.
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2018Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes, Molecular Systems Biology (2018) 14, e7899.
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2018Recent advances in understanding how rod-like bacteria stably maintain their cell shapes, F1000Research 2018, 7(F1000 Faculty Rev):241.
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2017Mechanical strain-sensing implicated in cell shape recovery in Escherichia coli, Nat. Microbio. 2017; 2:17115.
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2016Architectural transitions in Vibrio cholerae biofilms at single-cell resolution, Proc. Natl. Acad. Sci. U.S.A. 2016 Mar; 113(14): E2066-72.
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2015Private: Differential interaction forces govern bacterial sorting in early biofilms, Elife 2015;4.
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2015Private: Gene Transfer Efficiency in Gonococcal Biofilms: Role of Biofilm Age, Architecture, and Pilin Antigenic Variation, J. Bacteriol. 2015 Jul;197(14):2422-31.
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+Voir la liste complète de publications
Lab News
February 2020 – Gizem and Eva’s joint effort is published in eLife. Congratulations!
January 2020 – Antoine’s paper on Class-A PBPs is accepted in eLife. Congratulations!
September 2019 – More major results online: Enno’s and Yuki’s manuscript on the role of surface expansion for cell-volume regulation is now on the bioRxiv! Antoine’s, Baptiste’s and Andrey’s manuscript on the repair function of cell-wall synthases is on bioRxiv!
August 2019 – Eva’s and Gizem’s paper on the biorxiv and under review!
March 2019 – Andrey Aristov joins the lab as a postdoc. Welcome!
November 2018 – Sven became EMBO Young Investigator.
October 2018 – Francois joined as a new PhD student. Welcome!
February 2018 – Antoine’s paper in collaboration with David Bikard’s lab got accepted at MSB: http://msb.embopress.org/content/14/3/e7899.
October 2017 – Alexandra started as a postdoc and Yuki as a PhD student. Welcome! September 2017 – Our collaborative work with the teams of Ariel Amir and Lars Renner became the cover story in the September issue of Nature Microbiology. See also this report on phys.org 
June 2017 – Eva and Antoine present their research at the EMBO meeting New Approaches and Concepts in Microbiology June 27-30.
June 2017 – The lab goes on a ‘cell shape’ retreat in Burghausen, Bavaria, together with the labs of collaborators Lars Renner, Ariel Amir, Ethan Garner and Uli Gerland.
April 2017 –Baptiste joins the lab as a postdoc. Welcome!
February 2017 – Leonie and Lorenzo join the lab as master students. Welcome!
December 2016 – Together with our collaborators Lars Renner, Ariel Amir, Ethan Garner and Uli Gerland, Sven receives a Life? grant of the Volkswagen foundation.
November 2016 – Nitai from the lab of Ilana Kolodkin-Gal (Weizmann) joins the lab to work on B. subtilis biofilms for a few months. Welcome!
October 2016 – Gizem joins the lab as PhD students. Welcome!
June 2016 – Sven and Eva present our recent findings on the dynamics of cell-wall enzymes at the Gordon Research Conference on Bacterial Cell Surfaces, and Eva wins the poster prize. Congrats!
June 2016 – Enno Oldewurtel joins the team as a postdoc. Welcome!
March 2016 – Eva receives a “PRESTIGE” postdoctoral fellowship. Congratulations!
March 2016 – Hélène and Irida join as a M2 students. Hélène works on protein-protein interactions using correlation spectroscopy. Irida will use biochemistry and genetics to study the cell-wall expansion machinery. Welcome!
February 2016 – Louis and Thomas from the interdisciplinary AIV master program join the lab for their master thesis projects. Welcome!
October 2015 – Sven receives an Emergences grant from the City of Paris.
October 2015 – After an excursion to the iGEM competition Antoine returns for his PhD under joint supervision in the Synthetic biology lab and in our lab. Welcome back!
October 2015 – Sven receives ERC starting grant!
October 2015 – Together with Paolo Pierobon, Jeanette Nguyen, and Chiara Fracassi, Sven teaches a course on the Dynamics of Living Systems within the Master program of the Centre de Recherche Interdisciplinaire.
Lab pictures
Contact
Sven van Teeffelen email: sven_at_pasteur_dot_fr phone : +33 (0)1 45 68 80 16 Marie-Claire Rozier (assistante) phone : +33 (0)1 45 68 87 43 Address: Institut Pasteur Laboratory of Microbial Morphogenesis and Growth Bâtiment 26 François Jacob (2e étage) 28, rue du Docteur Roux 75724 Paris Cedex 15