Groupe: Molecular Biology of Hepatitis B virus
Role of Spindlin1 in cccDNA transcriptional repression and hepatocarcinogenesis
HBV is a small DNA virus that induces acute and chronic liver diseases. Chronic hepatitis B is a major health problem since more than 50 % of HCC cases worldwide are related to HBV […]
Interferon induction, inflammation and stress in HCV infection and stress-related pathologies
While potentially able to activate an immune response, the Hepatitis C virus establishes in a chronic infection in the majority of patients with progressive inflammation and degradation of the liver over time. Intensive research […]
Interaction of HCV with the IFN and stress pathways
Cells respond to invasion by bacterial or viral pathogens with the production of IFNs and pro-inflammatory cytokines, as a first line of their innate immune response. This is due to their ability to detect […]
Transcriptional regulation of HBV cccDNA
The HBV cccDNA has been shown to be organized in a chromatin like structure associated with histone and none histone proteins including the viral core protein however its role on cccDNA regulation is poorly […]
Chronic infections with Hepatitis C (HCV) and Hepatitis B (HBV) viruses
Chronic infections with Hepatitis C (HCV) and Hepatitis B (HBV) viruses (which infect 170 and 350 million persons in the world, respectively) lead to development of cirrhosis and are responsible for 80% of hepatocellular […]
2017Viral load affects the immune response to HBV in mice with humanized immune system and liver, Gastroenterology 2017 Aug;153(6):1647-1661.e9.
2017Hepatitis B virus pregenomic RNA in hepatocellular carcinoma: A nosological and prognostic determinant, Hepatology 2017 Aug;.
2016Single-nucleotide-resolution mapping of HBV promoters in infected human livers and hepatocellular carcinoma, J. Virol. 2016 Sep;.
2016Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection, PLoS ONE 2016;11(2):e0148667.
2015HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase, J. Hepatol. 2015 Nov;63(5):1093-102.
2015Pesticides and Ostreid Herpesvirus 1 Infection in the Pacific Oyster, Crassostrea gigas, PLoS ONE 2015;10(6):e0130628.
2015Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline, J Psychiatry Neurosci 2015 May;40(3):151-61.
2015Hepatocellular carcinoma, Cold Spring Harb Perspect Med 2015 Feb;5(2):a021444.
2015Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections, Autophagy 2015;11(3):516-26.
2014The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1, PLoS Pathog. 2014 Sep;10(9):e1004343.
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