Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets
Scientific Background Differentiation of naïve CD4+ T lymphocytes into functionally distinct T helper cell subsets is essential for efficient immune responses against different types of pathogens. Effector T cell lineages selectively produce specific sets […]
2019NFAT primes the human RORC locus for RORγt expression in CD4 T cells, Nat Commun 2019 10;10(1):4698.
2019The IL-23/IL-17 pathway in human chronic inflammatory diseases – new insight from genetics and targeted therapies, Microbes Infect. 2019 Jun - Jul;21(5-6):246-253.
2019The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies, Genes Immun. 2019 05;20(5):415-425.
2015Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients, Elife 2015 Nov;4.
2014RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer’s disease, Neurobiol. Dis. 2014 Sep;69:169-79.
2014Dynamic regulation of the COP9 signalosome in response to DNA damage, Mol. Cell. Biol. 2014 Mar;34(6):1066-76.
2014RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain, J. Alzheimers Dis. 2014;39(4):727-40.
2013COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels, J. Biol. Chem. 2013 Sep;288(37):26668-77.
2013Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease, Blood 2013 Sep;122(10):1802-12.
2013RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice, PLoS ONE 2013;8(6):e66908.
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