Laboratoire

Génétique des Interactions Macromoléculaires

Responsable

Alain Jacquier

CNRS UMR3525

Département de Génomes et Génétique

• Genetics
• Genetics, Genomics
• Genomics
• Molecular and Structural Biology and Chemistry
• Molecular interactions
• Non coding RNA
• Protein synthesis, modification and turnover
• RNA synthesis, processing, modification and degradation
• Fungi
• Model systems
• Saccharomyces
• Saccharomyces cerevisiae
• Yeast

VOIR TOUSFermer

Présentation

Désolé, cet article est seulement disponible en Anglais Américain.

Groupes

Group

Cosmin Saveanu

Groupe: Dégradation de l’ARN et traduction

Group

Micheline Fromont-Racine

Groupe: Micheline Fromont-Racine

Membres

Alain Jacquier

Responsable de Structure

Responsable

Monique Moulin

Antonia Doyen

Lucia Oreus

Laurence Decourty

Cosmin Saveanu

Chef(fe) de Groupe

Micheline Fromont-Racine

Chef(fe) de Groupe

Frank Feuerbach

Post-doctorant(e)

Gwenaël Badis-Breard

Chercheur(euse) Permanent(e)

Simon Malesys

Ingénieur(e) de Recherche

Marine Dehecq

Etudiant(e) en thèse

Christophe Malabat

Ingénieur(e) de Recherche

Abdelkader Namane

Ingénieur(e) de Recherche

Elodie Zhang

Etudiant(e) en thèse

Alicia Chery – Faleme

Etudiant(e) en thèse

Anciens Membres

Luciana Lazar Stefanita

Quentin Defenouillere

Alice Lebreton

Yanhua Yao

Emilie Demoinet

Thomas Kergrohen

Projets

S. cerevisiae gene regulation in quiescence

In wild life, yeast cells are able to survive in severe conditions, without nutriment for a long period of time because the cell is able to enter in stationary phase. During this phase, the […]

A personal database system for large scale quantitative results exploration (Cassandre, PTR 463)

Cassandre is a project of personal database system, integrating a “user-friendly” interface to manage and explore multiple sets of large-scale experimental results in biology.Large-scale experiments that generate quantitative data, such as changes in the […]

Quality Control at the Ribosome

Gene expression is controlled and regulated by nuclear and cytoplasmic surveillance mechanisms in order to preserve the integrity of genetic information. Some of the mechanisms occur in the nucleus during transcription and maturation of […]

Diversity and stability of eukaryotic transcripts

We focus on RNA quality control mechanisms and their consequences for the cells. Our previous studies revealed, for example, unexpected properties of the transcription process, such as its high pervasiveness and the intrinsic bi-directionality […]

Non-sense mediated mRNA decay mechanisms

Non-sense mediated mRNA decay (NMD) is a fundamental and conserved mechanism with a major role in shaping the levels of individual RNAs in a eukaryotic cell by efficiently removing RNAs in which a stop […]

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

To explore the effects of combining mutations and thus, be able to better understand complex functional interactions in a cell, we developed a novel genetic screening method that combines the exhaustivity of the yeast […]

Publications

• 2016
  How cells kill a “killer” messenger - Saveanu C, Jacquier A - eLife
• 2016
  Rqc1 and Ltn1 prevent CAT-tail induced protein aggregation by efficient recruitment of Cdc48 on stalled 60S subunits - Defenouillere Q, Zhang E, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M - The Journal of biological chemistry
• 2015
  The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components - Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C - Antimicrobial agents and chemotherapy
• 2015
  Identification of Links Between Cellular Pathways by Genetic Interaction Mapping (GIM) (book chapter) - Malabat, C; Saveanu C - Yeast Functional Genomics: Methods and Protocols
• 2015
  Systematic Determination of Transcription Factor DNA-Binding Specificities in Yeast - Peña-Castillo L and Badis G. - Methods in Molecular Biology
• 2015
  Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase - Cordin O, Hahn D, Alexander R, Gautam A, Saveanu C, Barrass JD, Beggs JD - Nucleic acids research
• 2015
  Quality control of transcription start site selection by nonsense-mediated-mRNA decay - Malabat C, Feuerbach F, Ma L, Saveanu C, Jacquier A - eLife
• 2014
  mRNA Degradation and Decay (book chapter) - Fromont-Racine, M; Saveanu, C - Fungal RNA Biology
• 2014
  Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids - Daum B, Quax TE, Sachse M, Mills DJ, Reimann J, Yildiz Ö, Häder S, Saveanu C, Forterre P, Albers SV, Kühlbrandt W, Prangishvili D - Proceedings of the National Academy of Sciences of the United States of America
• 2014
  Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast - Decourty L, Doyen A, Malabat C, Frachon E, Rispal D, Séraphin B, Feuerbach F, Jacquier A, Saveanu C - Cell reports
• +
  Voir la liste complète de publications

Contact

Address
25-28 Rue du Docteur Roux
75015, Paris
France