Génétique des Interactions Macromoléculaires

Cellular mRNAs are subjected to a balance between synthesis and degradation, which determines the shape of the transcriptome and greatly participates to protein homeostasis. In addition to the general degradation pathways, which ensure the […]

Translation involves four main steps: initiation, elongation, termination and recycling. Each step is highly controlled and can be modulated depending on the mRNA characteristics. The first step begins with the binding of eIF3 to […]

Cassandre is a project of personal database system, integrating a “user-friendly” interface to manage and explore multiple sets of large-scale experimental results in biology. Large-scale experiments that generate quantitative data, such as changes in […]

Gene expression is controlled and regulated by nuclear and cytoplasmic surveillance mechanisms in order to preserve the integrity of genetic information. Some of the mechanisms occur in the nucleus during transcription and maturation of […]

We focus on RNA quality control mechanisms and their consequences for the cells. Our previous studies revealed, for example, unexpected properties of the transcription process, such as its high pervasiveness and the intrinsic bi-directionality […]

Non-sense mediated mRNA decay (NMD) is a fundamental and conserved mechanism with a major role in shaping the levels of individual RNAs in a eukaryotic cell by efficiently removing RNAs in which a stop […]

To explore the effects of combining mutations and thus, be able to better understand complex functional interactions in a cell, we developed a novel genetic screening method that combines the exhaustivity of the yeast […]

CRAW is a package which aim to compute and visualize the coverage of RNA seq experiments. The main feature of this tools is the coverage is computed on the both strands, and is centred […]