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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).

Présentation

Within our research laboratory, we investigate cell interactions occurring in a homeostatic condition and during and after an injury at the tissue level in both central nervous system (CNS) and skeletal muscle. CNS is protected by the blood-brain barrier and has a resident inflammatory cell population (microglial cells); therefore this is a tissue of choice for studying acute injury, like sepsis. On the other hand, skeletal muscle shows a striking ability to regenerate efficiently and is easily accessible. We use this tissue as a paradigm for chronic lesions and regeneration. In both situations, we aim to characterize tissue compartments and cell interactions through in vivo and in vitro approaches. In the CNS, we study the early involvement of the neurovascular unit during sepsis. In the skeletal muscle, we explore the role of stem cells and stromal partner cells (endothelial cells, macrophages, fibroblasts) at homeostasia and during regeneration.

Our major findings during the last year are (i) that microglial cells are activated very early in the brain after a peripheral infection and during septic shock, (ii) that muscle stem cells show an extreme ability to survive hypoxic environment, keeping with the existence of an hypoxic niche for satellite cells.

Sans titre
Brain histological imaging during sepsis (green: microglia, red: vessels: purple astrocytes)

 

We have also Expertise activities in Human & Comparative Pathology. We are promoting the analysis of animal models by assisting and educating in their pathological evaluation and to develop diagnosis, research and education in human pathology. We can be sollicitated for scientfic collaborations in the field of animal models. Three histopathologists coming from medical and veterinary education contribute to the choice of morphological approaches, the design of protocols, and perform the evaluation of microscopic slides. We master quality, flexible routine and innovative techniques, like low-melting point paraffin technique for immunohistochemistry of labile antigens, acrylic resin semi-thin sections, or large sections, on either animal or human samples. We also receive human cases for diagnosis and ancillary techniques, particularly in mycology and parasitology, and we have weekly interactions with the Centre National de Référence des Mycoses Invasives et Antifongiques (Head: Prof F. Dromer).

Membres

Anciens Membres

2000
2000
Name
Position
2015
2020
Jean Bardon
Undergraduate Student
2015
2020
Alessandra Beretta
Undergraduate Student
2015
2020
Aurore Besnard
Post-doc
2015
2020
Laurence Fiette
Permanent Researcher
2015
2020
Mathilde Latil
PhD Student
2015
2020
Claire Latroche
PhD Student
2015
2020
Flora Magno De Jesus Oliveira
PhD Student
2015
2020
Quentin Pascal
Undergraduate Student
2015
2020
Dania Zhivaki
Post-doc
2015
2020
Cyril Longé
Graduate Student
2015
2020
Jean Mantz
Permanent Researcher
2015
2020
Wajih Ben Hassen
PhD Student
2015
2020
Nassima Messal
Post-doc
2015
2020
Richard Lo-Man
Group Leader
2015
2020
Pierre Rocheteau
Post-doc
2015
2020
Pierre Goossens
Permanent Researcher
2015
2020
Aurélien Mazeraud
PhD Student
2015
2020
Inès Mouyokolo
Administrative Staff
2015
2020
Anthony Yasmann
PhD Student
2015
2020
Luis Henrique Angenendt Da Costa
PhD Student
2015
2020
Cássia Righy Shinotsuka
Visiting Scientist
2015
2020
Claire Bastard
Undergraduate Student
2015
2020
Aurélien Seguier
Undergraduate Student
2015
2020
Benjamin Picard
Undergraduate Student
2015
2020
Lucie Duarte
Undergraduate Student
2015
2020
David Briand
Technician
2015
2020
Gabriela Ferreira de Medeiros
Non-permanent Researcher
2015
2020
Lorna Guéniot
PhD Student
2015
2020
Franck Verdonk
Post-doc
2015
2020
Patricia Flamant
Technician
2015
2020
Isabelle Mouyna
Permanent Researcher
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Cours

Cours d’histologie du 9 au 13 mars 2020

Le pôle formation RH et la plateforme d’histologie vous annoncent l’organisation du premier cours « d’initiation aux techniques d’histologie et d’immunohistologie » du 9 au 13 mars 2020 sur le campus.   Objectifs du cours : • Acquérir des […]

2020-03-09 09:00:00 2020-03-13 16:30:00 Europe/Paris Cours d’histologie du 9 au 13 mars 2020 Le pôle formation RH et la plateforme d’histologie vous annoncent l’organisation du premier cours « d’initiation aux techniques d’histologie et d’immunohistologie » du 9 au 13 mars 2020 sur le campus.   Objectifs du cours : • Acquérir des […] 25-28 Rue du Dr Roux, 75015 Paris, France

Mousepath 2015

This workshop provided three days of up to date training in experimental and comparative pathology. The program explored mouse models of cancer, diseases of the skin, muscle, bone, special senses, and immune system. It […]

2015-06-16 14:00:00 2015-06-19 Europe/Paris Mousepath 2015 This workshop provided three days of up to date training in experimental and comparative pathology. The program explored mouse models of cancer, diseases of the skin, muscle, bone, special senses, and immune system. It […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Projets

Projet Transversal

Services

Histology Service

News Cours d’histologie du 9 au 13 mars 2020 About us Our laboratory offers state-of the art large histotechnological laboratory with a team of specialized Engineers and histopathologists from medical and veterinary education. Our […]

Équipements

Cryostat in Safety level 3 facility • LEICA • CM 3050S

This material allows us to perform frozen sections from human or animal samples infected with safety level 3 pathogens. Please contact us if needed

Automated tissue processor • LEICA • TP 1050

This material is needed for routinely dehydration and pre-embedding of tissue samples in paraffin. We can perform the pre-embedding of your tissue samples Please contact us if needed

Digital camera • NIKON • DSRi2

High quality bright field microphotographs can taken with this material, which is connected to a NIKON 50i microscope. People from other laboratories can have access to this equipment Please contact us if needed  

Vibratome • LEICA • VT 1200S

Vibrating microtomes (vibratomes) allows to cut tissues without freezing or embedding. 50-100 um sections can be performed to study the tissue morphology in 3D or to preserve enzyme and cell activities within thick slices. […]

Cryostat • LEICA • CM 3050S

This material is needed  to perform frozen sections.  People trained in frozen sectioning  from other laboratories can use this material under our supervision. Please contact us 

Automated slide stainer • MICROM • HMS 740

  This automat provides reproducible automated, high quality standard stainings for paraffin or frozen histological sections.   Please contact us if you need to stain histological sections (Hematoxylin-Eosin or special stains) Please contact us […]

Microtome • LEICA • RM 2245

A microtome is needed to perform paraffin sections. Trained people from other laboratories can have access to this equipment under our supervision Please contact us if needed  

Paraffin embedding station • LEICA • EG 1150

The paraffin embedding station is needed to routinely prepare paraffin blocks. We can perform the embedding of your tissue samples Please contact us if needed

Slide scanner • ZEISS • Axio Scan.Z1

The Axio Scan allow to digitize histological sections and  create high-quality virtual slides. Both bright field and fluorescent sections can be digitalized. Virtual slides can be then be kept and observed or used for […]

Publications

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Contact

Phone: +33 (1) 40 61 31 32 Email: neuropatho@pasteur.fr Address 28 Rue du Docteur Roux 75015, Paris France