One of our objectives is to understand the interplay between innate and adaptive immunity in chronic viral infections, in order to identify mechanisms responsible for the lack of immune control of persistent viruses, such as HIV or HPV. In particular, we dissect the modalities of the cross-talk between some innate effectors, i.e. dendritic cells (DCs) and natural killer (NK) cells, and their impact on adaptive immunity. Moreover, we have been involved in the search for new pathways of HIV entry and we contributed to show the implication of purinergic receptors in the process of fusion mediated by HIV-1-envelope. Finally, we have set up an Immunomonitoring Platform evaluating, in phase I and II vaccine trials, the immunogenicity of new vaccine candidates specific for influenza, malaria, shigellosis, anthrax or cancer.
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Connexions
Membres
Marie-Lise Gougeon
Responsable de Structure
Responsable
Anciens Membres
Projets
Projet Transversal
Publications
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2014Causal analysis of H1N1pdm09 influenza infection risk in a household cohort, J Epidemiol Community Health 2015 Mar;69(3):272-7.
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2014Peripheral and local human papillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral lichen planus, J. Invest. Dermatol. 2015 Feb;135(2):418-24.
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2014Suppression by thimerosal of ex-vivo CD4+ T cell response to influenza vaccine and induction of apoptosis in primary memory T cells, PLoS ONE 2014;9(4):e92705.
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2014Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization, Hum Vaccin Immunother 2014;10(8):2328-35.
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2013Clinical validation of IFNγ/IL-10 and IFNγ/IL-2 FluoroSpot assays for the detection of Tr1 T cells and influenza vaccine monitoring in humans, Hum Vaccin Immunother 2014;10(1):104-13.
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2013Analysis of NKp30/NCR3 isoforms in untreated HIV-1-infected patients from the ANRS SEROCO cohort, Oncoimmunology 2013 Mar;2(3):e23472.
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2012IFN-α and TRAIL: a double edge sword in HIV-1 disease?, Exp. Cell Res. 2012 Jul;318(11):1260-8.
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2011Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?, Curr Opin HIV AIDS 2011 Sep;6(5):364-72.
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2010Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk–a pivotal role of HMGB1, PLoS Pathog. 2010 Apr;6(4):e1000862.
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2008HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk, PLoS ONE 2008;3(10):e3601.
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