Description: The main objective of the project is to assess the interactions between malnutrition and modifications of the gut microbiota in order to propose new strategies of treatment for malnourished children tacking into account the microbiological versant of the problem. The MALINEA project will be implemented in Madagascar, Niger, Central African Republic and Senegal for a period of three years. This multi-sites project brings the expertise and skills of the International Network of Pasteur Institutes together with the NGOs Action against Hunger and GRET.
Goal: The MALINEA project is divided into three main parts:
Part 1: Evaluation of the association between disturbances of the digestive microflora and malnutrition.
Part 2: Improvement of the management of moderate acute malnutrition (MAM) by acting on this microbial component. This part is a multicenter randomized clinical trial comparing the effectiveness (recovery at 3 months) of 3 refeeding protocols: 1/ CSB ++ standard treatment (Fortified Corn-Soy Blend) 2/ CSB ++ associated with antibiotic 3/ CSB ++ associated with prebiotic.
Part 3: Improvement of local capacity/knowledge on nutrition by promoting the transfer of know-how and partnerships between research institutes and fight against malnutrition programs. Scholarships will allow students and young researchers to be involved in the project, and to be trained in the methods used.