The Whole-Exome Sequencing is carried out on the HiSeq2500 within 4 to 5 days. The commercial capture kits of exonic regions are regularly improved. The Nextera Rapid Capture Expanded Exome delivers 62 Mb of genomic content, including exons, untranslated regions (UTRs), and miRNA and requires only 50 ng of DNA. A pipeline, based on the Genome Analysis Toolkit (GATK) developed at the Broad Institute, is available for the analysis of batches of WES data. It runs on the internal cluster BIC (today, 100 Compute nodes). CNV analysis is also done.