Lutter contre la résistance aux antibiotiques
Les antibiotiques éliminent de manière efficace les bactéries pathogènes avec le plus souvent peu d’effets indésirables. Ces médicaments “miracles” ont eu depuis plus de 70 ans un impact majeur pour améliorer la santé humaine […]
Outbreak Investigation Taskforce
Les épidémies récentes d’Ebola en Afrique de l’Ouest, de coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV), de fièvre jaune en RDC, Angola et Brésil, de grippe aviaire en Asie et en Afrique, mais aussi […]
Le projet Afribiota
Comprendre les causes de la malnutrition chronique Contexte Un enfant sur quatre âgé de moins de 5 ans dans le monde souffre de malnutrition. Celle-ci est en cause dans près de la moitié de […]
Neonatal acquisition of ESBL-PE in the community of a Low-Income Country Severe bacterial infections are a leading cause of neonatal deaths, with low income countries (LICs) bearing the highest burden. In LICs, neonatal bacterial […]
The European Virus Archive Goes Global
EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]
Field Test for Rabies Diagnostic (FiTeRaD)
The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]
PTR 161 – EVinCA&M: Epidemiology and Genetic Diversity of Enteroviruses in Central Africa and in Madagascar
Plasmodium vivax Invasion Pathways into Human Reticulocytes
Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]
Dynamics of Gut Microbiota
Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]
CHART: Bacterial Acquisition Routes In Neonates
Children’s Antibiotic Resistance colonization and Route of Transmission. The aim of this program is to assess the transmission of enterobacteria resistant to 3rd generation cephalosporines (EBRCIIIG) in hospitalized neonates in two low income countries […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
A descriptive analysis of pertussis in 4 different regions of the world Coordinated by Fabien Taieb, physician affiliated with the Center for Translational Science at the Institut Pasteur, responsible for the coordination of the […]
NéoVac (Neonatal Vaccination against Hepatitis B in Africa)
Chronic infection with hepatitis B virus (HBV) is an important cause of premature adult deaths in sub-Saharan Africa (SSA), due to liver cancer or cirrhosis. To reduce the disease burden, it is critical to […]
Enterovirus A 71 (EV-A71) is an emerging pathogen that is circulating worldwide and mostly causes hand, foot, and mouth disease (HFMD) in children. However, in many cases, EV-A71 causes neurological complications, such as meningitis, […]
Community-based home visit intervention in sub-Saharan Africa to improve Hepatitis B vaccination coverage at birth and neonatal survival (Neovac)
The aim of this study is to develop and evaluate a community-based home visit intervention in sub-Saharan Africa to improve the coverage of a timely birth dose of HBV vaccine and neonatal care practices […]
Population biology of the bacterial pathogen Klebsiella pneumoniae
Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics. In this project we aim to understand the ecological, epidemiological and […]
Alerting and Surveillance for Infectious Disease Epidemics
In a context of increasing globalization of trade, the growth in international flows of travelers and goods fuels the spread of infectious diseases. The need for a global alert and response network for infectious diseases […]
2020Development of a New Internally Controlled One-Step Real-Time RT-PCR for the Molecular Detection of Enterovirus A71 in Africa and Madagascar., Front Microbiol 2020 ; 11(): 1907.
2019Epidemiological characteristics of an urban plague epidemic in Madagascar, August-November, 2017: an outbreak report, Lancet Infect Dis 2019 Mar;.
2019High permissiveness for genetic exchanges between enteroviruses of species A, including enterovirus 71, favours evolution through intertypic recombination in Madagascar, J. Virol. 2019 Jan;.
2018Whole Genome Sequencing of Enteroviruses Species A to D by High-Throughput Sequencing: Application for Viral Mixtures, Front Microbiol 9:2339.
2018Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project., BMC Pediatr. 2018 Jul 19;18(1):236.
2016Whole Genome Sequencing of Enterovirus species C Isolates by High-throughput Sequencing: Development of Generic Primers, Front. Microbiol. 7:1294.
2014Molecular comparison and evolutionary analyses of VP1 nucleotide sequences of new African human enterovirus 71 isolates reveal a wide genetic diversity, PLoS ONE 2014;9(3):e90624.
2011Genetic relationship between cocirculating Human enteroviruses species C, PLoS ONE 2011;6(9):e24823.
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Localisation: Institut Pasteur in Madagascar, B.P. 1274 101 Antananarivo, Madagascar