Outbreak Investigation Taskforce
Les épidémies récentes d’Ebola en Afrique de l’Ouest, de coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV), de fièvre jaune en RDC, Angola et Brésil, de grippe aviaire en Asie et en Afrique, mais aussi […]
The Southeast Asia encephalitis project
Une approche intégrative pour mieux comprendre et combattre l’encéphalite infectieuse de l’enfant Les encéphalites sont des infections aigües du système nerveux central associées à des troubles neurologiques. Les étiologies les plus fréquentes sont d’origine bactériennes ou […]
300 à 400 millions de cas de dengue surviennent chaque année dans le monde entier. Se diffusant rapidement, plus de 40% de la population mondiale est maintenant à risque de contracter la dengue. Ce […]
Understanding protective humoral immunity in asymptomatic dengue-infected individuals
Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
The European Virus Archive Goes Global
EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]
Field Test for Rabies Diagnostic (FiTeRaD)
The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]
Targeting Malaria Epigenetics
Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
Background and Rationale
Despite the immense and encouraging progresses made over the last decade, malaria remains a major public health concern. Intensifying efforts against malaria along with an unprecedented increase in public and private funding have […]
This project aims to shift from disease control to reverse conservation biology of pathogens in order to devise new public health strategies. Our objective is a qualitative understanding of the “niche” of two different […]
A descriptive analysis of pertussis in 4 different regions of the world Coordinated by Fabien Taieb, physician affiliated with the Center for Translational Science at the Institut Pasteur, responsible for the coordination of the […]
DENFREE consortium – Dengue Framework for Resisting Epidemics in Europe
The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]
Enterovirus A 71 (EV-A71) is an emerging pathogen that is circulating worldwide and mostly causes hand, foot, and mouth disease (HFMD) in children. However, in many cases, EV-A71 causes neurological complications, such as meningitis, […]
Mosquito genetic variation in dose-response to dengue virus
This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]
Population biology of the bacterial pathogen Klebsiella pneumoniae
Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics. In this project we aim to understand the ecological, epidemiological and […]
Alerting and Surveillance for Infectious Disease Epidemics
In a context of increasing globalization of trade, the growth in international flows of travelers and goods fuels the spread of infectious diseases. The need for a global alert and response network for infectious diseases […]
Enterovirus EV71 pathogenesis
This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.
Our main objective is to increase the knowledge regarding the human virome during homeostasis and diseases. We mainly focus on: immunocompromised patients, where new pathogens and new associations between known pathogens and diseases at found at higher frequency than […]
2019A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice, Front. Immunol. 2019 Jun;10 (1424).
2018Dengue modeling in rural Cambodia: Statistical performance versus epidemiological relevance, Epidemics 2018 Aug;.
2017Increased adaptive immune responses and proper feedback regulation protect against clinical dengue., Sci Transl Med 2017 Aug; 9(405): .
2016Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana, Malar. J. 2016 Nov;15(1):540.
2016A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study, Lancet Infect Dis 2017 Feb;17(2):174-183.
2016Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes, Malar. J. 2016 Apr;15:206.
2012Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia, Antimicrob. Agents Chemother. 2013 Feb;57(2):914-23.
2010Ralstonia pickettii community-acquired pneumonia in Cambodia, Int. J. Tuberc. Lung Dis. 2010 Dec;14(12):1653-4.
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