Thierry has been at the Pasteur Institute since 1983 where he worked on Plasmodium falciparum and published more than 20 papers on that topic. After an experience on Yersinia, he joined our lab in January 2006 where he runs numerous projects related to flagellum formation. Also known as Shiva, Thierry uses biochemistry, immunology, molecular and cellular biology on a day-to-day basis. He recently specialised in scanning electron microscopy working at the EM platform of the Institute on virtually all the lab subjects. Trypanosomes, Plasmodium, ciliates, mammalian cilia, mouse kidney, fly tissues… nothing can hide from his hawk eyes! His recent projects are the analysis of the IFT dynein motors where he characterised four different subunits and their interactions with the IFT complexes.
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2019IFT25 is required for the construction of the trypanosome flagellum, J. Cell. Sci. 2019 Feb;.
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2018A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes, Curr. Biol. 2018 ;28(23):3802-3814.
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2018Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum, J. Cell Biol. 2018 Oct;217(12):4284-4297.
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2017Flagellar incorporation of proteins follows at least two different routes in trypanosomes, Biol. Cell 2018 110(2):33-47.
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2015The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies, PLoS ONE 2015;10(7):e0133676.
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2014The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions, Mol. Biol. Cell 2014 Sep;25(17):2620-33.
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2014The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status, Mol. Microbiol. 2014 Jul;93(1):80-97.
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2014The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport, Elife 2014;3:e02419.
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2014Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics, Mol. Cell Proteomics 2014 Jul;13(7):1769-86.
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2013Molecular basis of tubulin transport within the cilium by IFT74 and IFT81, Science 2013 Aug;341(6149):1009-12.
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