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Projets
Anciennes Équipes
CV
(EN)
Positions
2013-Present: Postdoc at Pasteur Institute, Paris (Focus: Comparative genomics of methylomes and methylation systems)
2010-2012: Postdoc at Instituto Superior Técnico, Lisbon (Focus: Genetic instability of stem cells)
Education
2008-2009: PhD visiting student at MIT and Harvard Med. School (Focus: genome engineering; accelerated genome evolution)
2006-2009: PhD student at Instituto Superior Técnico, Lisbon (Focus: Genetic instability in DNA biopharmaceuticals)
2005: Research Assistant at University College London (Focus: Identification of secondary metabolites in Actinomycetes)
1999-2005: MSc in Biological Engineering at Instituto Superior Técnico, Lisbon
Areas of Competence/Expertise
Bioinformatics, comparative genomics, methylomics, genome instability, biotechnology, biopharmaceuticals, stem cells, gene therapy
Reviewing Activities
Nucleic Acids Research, Scientific Reports, Bioinformatics, Molecular Biology and Evolution, BMC Genomics, FEMS Microbiology Letters, Cell Death and Differentiation, PLoS ONE, Cell and Tissue Research, etc.
Publications
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2017The chromosomal organization of horizontal gene transfer in bacteria, Nat Commun 2017 Oct;8(1):841.
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2016Regulation of genetic flux between bacteria by restriction-modification systems., Proc Natl Acad Sci U S A. 2016 May 17;113(20):5658-63. doi: 10.1073/pnas.1603257113. .
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2015Advances in the Development of Biotherapeutics, Biomed Res Int 2015;2015:793876.
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2014Concise review: Genomic instability in human stem cells: current status and future challenges, Stem Cells 2014 Nov;32(11):2824-32.
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2014The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts, Nucleic Acids Res. 2014;42(16):10618-31.
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2014Evidence that the insertion events of IS2 transposition are biased towards abrupt compositional shifts in target DNA and modulated by a diverse set of culture parameters, Appl. Microbiol. Biotechnol. 2014 Aug;98(15):6609-19.
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2013Marker-free plasmids for biotechnological applications – implications and perspectives, Trends Biotechnol. 2013 Sep;31(9):539-47.
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2013An appraisal of human mitochondrial DNA instability: new insights into the role of non-canonical DNA structures and sequence motifs, PLoS ONE 2013;8(3):e59907.
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2012Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells, Stem Cell Res 2012 Nov;9(3):225-36.
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2012Protein-DNA interactions define the mechanistic aspects of circle formation and insertion reactions in IS2 transposition, Mob DNA 2012;3(1):1.
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