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© Pierre Gounon
Virus influenza purifié, agent de la grippe. Ce virus enveloppé possède un génome fragmenté : 8 segments d'ARN négatif protégés par une nucléocapside.
Membre: Chef(fe) de Projet

Meriadeg Le Gouil

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Employment History / Scientific Experience:

  • 01/2015 : Member of the Ebola diagnostic team at the Center for treatment and care of Ebola fever patients in Macenta, Guinea.

  • 07/2014 – actual: Researcher, Institut Pasteur Paris “Environment and Infectious Risks” research & expertise unit & Université de Caen Basse-Normandie (Unité “Risques microbiens”) . Core mission: co-PI (with Pr. Astrid Vabret) and work-package leader of the EPICOREM ANR project, emergence threat of coronaviruses / HTS implementation.
  • 07/2012 – 06/2014: Post-doctoral fellow, then Assistant professor (2014), Institut Pasteur Paris, in the CIBU laboratory. Core mission: coronaviruses (SARS-CoV / MERS-CoV) and poxviruses survival in the environment, phylogenetics and HTS implementation.
  • 07/2009 – 06/2012 : Post-doctoral fellow, Institut Pasteur Paris, in the CIBU laboratory. Core mission: In charge of the virological aspects for elucidating the etiology of pediatric encephalitis epidemics (Acmong project), in collaboration with the Vietnamese NIHE (Hanoï).
  • 2005 / 2008: PhD program (National Museum of Natural History, Paris), hosted in the IRD / CVVD laboratory at the Mahidol University Faculty of Science (Center for Vector and Vector-borne Diseases) and in the CIBU laboratory (Institut Pasteur, Paris).

Education:

  • 04/2016: Training and formation on Animal use for scientific purposes (Study designer).
  • 2005 – 2008: Science PhD. Doctoral school: Diversity of Life, Paris National Museum of Natural History; Dpt Sytematic and Evolution, UMR MNHN/CNRS 5202, OSEB (Origin Structure and Evolution of Biodiversity). Co-hosted by Institut de Recherche pour le Développement (IRD) and Institut Pasteur Paris. Subject : Ecological relations between viruses and bats – Coronaviruses, SARS-CoV and other viruses from Chiroptera: detection, characterization and ecology.
  • 2004: Master 2 degree, Phylogeny and Systematic Postgradutate certificate (DEA) within the Paris National Museum of Natural History – (MNHN PARIS). Hosted by the UMR BIPAR (Molecular Biology and Immunology of Parasites and fungi) of the Alfort National Veterinary School (ENVA). Subject: Phylogeny and Co-evolution of Pneumocystis and their mammalian hosts. In the laboratory of Pr. J. Guillot, ENVA.
  • 2003: Master 1 degree (Maîtrise), Ecosystems and Populations Biology, University Rennes 1 (biostatistics, ecosystems functioning and communities interaction, parasitology, modelling, adaptations to environmental conditions, eco-ethology.
  • 2002: Biology Degree: Licence of Organisms and Populations Biology at the University of RENNES 1 (Biochemistry, structure and function of the bio-molecules, genetic, cellular biology; Specialization: phylogeny, zoology, evolution, biological bases of behaviours regulation and relations between organisms.).

Scientific Grants and Fundings:

  • 2014 – 2017: ANR (French grant) EPICOREM (Eco-Epidemiology of Coronaviruses, from wildlife to Human: Emergence threat assessment); ANR contribution: € 600,000. Scientific co-director and Task leader: Diversity, phylogenetics, evolution of coronaviruses and dynamics of quasi-species communities.
  • 2012 – 2014: PREDEMICS EU founded project; EU contribution : € 11,758,352. Emerging viruses (coronaviruses, poxviruses) detection, characterization and study of the survival in the environment.
  • 2009 – 2012: ANR 08 MIEN 003 project (€ 500,000, collaboration between the Institut Pasteur Paris and the National Institute of Health Hanoï). Acmong encephalitis in North Vietnam : virological, epidemiological, clinical, et immunological aspects of an emerging viral disease.
  • 2005 – 2008: Carrefour International Fondation. € 60,000 PhD. grant for the “Detection and characterization of SARS-like coronaviruses in bats and other mammals in South-East Asia”.

Conferences & Communications (selection):

Enteroviruses associated with pediatric encephalitis outbreaks during litchi harvesting in northern Vietnam.

Le Gouil, M., Phan Thi, N.; Do Phuong, L.; Paireau, J.; Cheval, J.; Ngu, Duy N.; Hebert, C.; Nguyen, Hai T.; Nguyen, T. H.; Lortholary, O.; Burguière, A.; Manuguerra, J.C.; Fontanet, A. and Eloit, M. Scientific Symposium of the Institut Pasteur International Network, Paris, September 10th -13th, 2014.

High Throughput Sequencing without “a priori” applied to pathogen detection and characterization in biological samples.

  1. Ar Gouilh, J.M. Thiberge, L. Diancourt, M. Vandenbogaert, .C. Manuguerra, V. Caro. Amazonian conference on emerging and infectious diseases. Institut pasteur Cayenne, French Guyana, September 26th – 28th, 2014.

Unbiased HTS of MERS-CoV from clinical samples.

M Ar Gouilh, Expert meeting to review the WHO interim recommendations on the laboratory detection of middle east respiratory syndrome coronavirus, WHO, Lyon, France, June 10th -11th 2014.

Unbiased HTS of MERS-CoV from clinical samples.

M Ar Gouilh, J.M. Thiberge, L. Diancourt, M. Vandenbogaert, C. Batéjat, S. van Der Werf, J. Poissy, A. Burguière, V. Enouf, J.C. Manuguerra, V. Caro. XIIIth International Nidovirus Symposium, Salamanca – Spain, June 1st – 6th 2014.

MERS-CoV genomes deep sequenced directly from clinical specimens originating from patients involved in a nosocomial transmission event.

  1. Ar Gouilh, J.M. Thiberge, L. Diancourt, M. Vandenbogaert, C. Batéjat, S. van Der Werf, J. Poissy, A. Burguière, V. Enouf, J.C. Manuguerra, V. Caro. International meeting on epidemiological markers, Institut Pasteur, October 2nd – 5th 2013.

Coronavirinae : du SRAS-CoV 2003 au MERS-CoV 2013, Actualités et Évolutions des Betacoronavirus.

  1. Le Gouil, A.M. Burguière, J.C. Manuguerra. Conference: Actualités sur l’infection à MERS CoV. Société de Pathologie Infectieuse de Langue Française (SPILF) / Réseau de Coordination du Risque Épidémiologique et Biologique (COREB). UFR de Médecine Paris Diderot – Bichat. June 6th 2013.

The de novo assembling of a big viral genome: the Monkeypoxvirus Soudan 2005.

  1. Le Gouil, M. Vandenbogaert, V. Caro, J.-C. Manuguerra. Journées assemblages, Institut pasteur, Paris 18th March 2013.

Coronavirinae de Chiroptères, le danger vient-il du ciel?

  1. Le Gouil. RICAI 2012 – CNIT Paris, La Défense – 21-22 November 2012

SARS-Coronavirus ancestor’s foot-prints in South-East Asian bat colonies : A phylogeographic perspective.

  1. Le Gouil, S. Puechmaille, J.-P. Gonzalez, E. Teeling, P. Kittayapong, J.-C. Manuguerra. International Conference on Infectious Diseases, Bangkok, Thailand, 14-16 June 2012.

Persistance of SARS-CoV in bat (Rhinolophus ferrumequinum) feces, implications for circulation of Coronavirinae in nature.

  1. Le Gouil, J.-C. Manuguerra. International Conference on Infectious Diseases, Bangkok, Thailand, 14-16 June 2012.

SARS-Coronavirus ancestors foot-prints in South-East Asia: bat colonies and the biodiversity refuge theory.

  1. Le Gouil, S. Puechmaille, J.-P. Gonzalez, E. Teeling, P. Kittayapong, J.-C. Manuguerra. International Meeting on Emerging Diseases and Surveillance, Vienna, Austria February 4-7, 2011.

– Bats and viruses.

Ar Gouilh M. and Puechmaille S. XIth European Bat Research Symposium, Cluj-Napoca, Romania, 18th-22nd August 2008.

– Bat-borne viral zoonoses and emergence – features and tools

Ar Gouilh M. Prince of Songkla University, Hat-Yai, Thailand, 12th March 2008.

– Bats: Host, Vector and Reservoir of Emerging Viral Diseases

J.P. Gonzalez, M. Ar Gouilh, X. Pourrut, E. Leroy. International Meeting on Emerging Diseases and Surveillance (IMED), Vienna, Austria, 2007

– Bat cell culture, a new tool for Virology or the connection between lab work and field observations in diseases emergence topics.

Meriadeg Ar Gouilh, Jean Claude Manuguerra & J. Jean Paul Gonzalez. XIV International Bat Research Conference & 37th NASBR, Mérida, Yucatán, Mexico, 19th-23rd August 2007.

– Unveiling fundamentals of bat borne viral zoonoses emergence: SARS, Ebola and Nipah examples.

Meriadeg Ar Gouilh, Eric Leroy & J. Jean Paul Gonzalez. XIV International Bat Research Conference & 37th NASBR, Mérida, Yucatán, Mexico, 19th-23rd August 2007.

Peers Reviewed Publications:

First complete genome sequence of European Turkey coronavirus suggests complex recombination history related with US Turkey and guinea fowl coronaviruses. Brown PA, Touzain F, Briand FX, Ar Gouilh M, Courtillon C, Allée C, Lemaitre E, De Boisséson C, Blanchard Y, Eterradossi N. J Gen Virol. 2015 Nov 19. doi: 10.1099/jgv.0.000338.
Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes. Kin N, Miszczak F, Lin W, Gouilh MA, Vabret A; EPICOREM Consortium. Viruses. 2015 May 7;7(5):2358-77. doi: 10.3390/v7052358.
Rouxiella chamberiensis gen. nov., sp. nov., a member of the family Enterobacteriaceae isolated from parenteral nutrition bags. Le Flèche-Matéos A, Levast M, Lomprez F, Arnoux Y, Andonian C, Perraud M, Vincent V, Ar Gouilh M, Thiberge JM, Vandenbogaert M, Diancourt L, Caro V, Burguière AM, Manuguerra JC. Int J Syst Evol Microbiol. 2015 Jun;65(Pt 6):1812-8. doi: 10.1099/ijs.0.000179. Epub 2015 Mar 6.

Potential Role of Fresh Water Apple Snails on H5N1 Influenza Virus Persistence and Concentration in Nature. M. Souris, D. Gonzalez, W. Wiriyarat, K. Chumpolbanchorn, S. Khaklang, S. Ninphanomchai, W. Paungpin,S. Chaiwattanarungruengpaisan, L. Sariya, D. Selenic, M. AR Gouilh, P. Kittayapong and J.P. Gonzalez. Air and Water borne diseases. 2015, jan. 4:1. http://dx.doi.org/10.4172/2167-7719.1000119.

Microbial molecular markers and epidemiological surveillance in the era of high throughput sequencing: an update from the IMMEM-10 Conference. Sylvain Brisse, Carina Brehony, Teresa Conceição, Meritxell Cubero, Corinna Glasner, Meriadeg Le Gouil, Aurélie Renvoisé, Sam Sheppard, Lucy Weinert. Research in Microbiology, 2014 Jan.

A member of a new Picornaviridae genus is shed in pig feces. Sauvage V, Ar Gouilh M, Cheval J, Muth E, Pariente K, Burguiere A, Caro V, Manuguerra JC, Eloit M. J Virol. 2012 Sep;86(18):10036-46. doi: 10.1128/JVI.00046-12. Epub 2012 Jul 11. PMID: 22787214
Human skin microbiota: high diversity of DNA viruses identified on the human skin by high throughput sequencing. Foulongne V, Sauvage V, Hebert C, Dereure O, Cheval J, Gouilh MA, Pariente K, Segondy M, Burguière A, Manuguerra JC, Caro V, Eloit M. PLoS One. 2012;7(6):e38499. Epub 2012 Jun 19. PMID: 22723863
The evolution of sensory divergence in the context of limited gene flow in the bumblebee bat. Puechmaille SJ, Gouilh MA, Piyapan P, Yokubol M, Mie KM, Bates PJ, Satasook C, Nwe T, Bu SS, Mackie IJ, Petit EJ, Teeling EC. Nat Commun. 2011 Dec 6;2:573. doi: 10.1038/ncomms1582. PMID: 22146392
Human polyomavirus related to African green monkey lymphotropic polyomavirus. Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, Manuguerra JC, Richardson J, Lecuit M, Burguière A, Caro V, Eloit M. Emerg Infect Dis. 2011 Aug;17(8):1364-70. PMID: 21801611
SARS-Coronavirus ancestor’s foot-prints in South-East Asian bat colonies and the refuge theory. Gouilh MA, Puechmaille SJ, Gonzalez JP, Teeling E, Kittayapong P, Manuguerra JC. Infect Genet Evol. 2011 Oct;11(7):1690-702. Epub 2011 Jul 8. PMID: 21763784
Identification of the first human gyrovirus, a virus related to chicken anemia virus. Sauvage V, Cheval J, Foulongne V, Gouilh MA, Pariente K, Manuguerra JC, Richardson J, Dereure O, Lecuit M, Burguiere A, Caro V, Eloit M. J Virol. 2011 Aug;85(15):7948-50. Epub 2011 Jun 1. PMID: 21632766
Identification of a novel neuropathogenic Theiler’s murine encephalomyelitis virus. Buckwalter MR, Nga PT, Gouilh MA, Fiette L, Bureau JF, Laird ME, Buchrieser J, Ozden S, Cheval J, Eloit M, Manuguerra JC, Gessain A, Brey PT, Fontanet A, Albert ML. J Virol. 2011 Jul;85(14):6893-905. Epub 2011 May 4. PMID: 21543488
White-nose syndrome fungus (Geomyces destructans) in bat, France. Puechmaille SJ, Verdeyroux P, Fuller H, Gouilh MA, Bekaert M, Teeling EC. Emerg Infect Dis. 2010 Feb;16(2):290-3. PMID: 20113562

Characterization and multiplex genotyping of 16 polymorphic microsatellite loci in the endangered bumblebee-bat, Craseonycteris thonglongyai (Chiroptera: Craseonycteridae) Puechmaille S, Yokubol M, Piyapan P, Ar Gouilh M, Khin Mie Mie, Bates P, Satasook C, Tin Nwe, Si Si Hla Bu, Mackie I and Teeling E. Conservation Genetics 2009[doi:10.1007/s10592-008-9691-1]

Population size, distribution, threats and conservation status of two endangered bat species: Craseonycteris thonglongyai and Hipposideros turpis. Puechmaille S, Soisook P, Yokubol M, Piyapan P, Ar Gouilh M, Khin Mie Mie, Khin Khin Kyaw, Mackie I, Bumrungsri S, Dejtaradol A, Tin Nwe, Si Si Hla Bu, Satasook C, Bates P and Teeling E. Endangered Species Research 2009. [doi:10.3354/esr00157]

Change in Japanese encephalitis virus distribution, Thailand. Nitatpattana N, Dubot-Pérès A, Gouilh MA, Souris M, Barbazan P, Yoksan S, de Lamballerie X, Gonzalez JP. Emerg Infect Dis. 2008 Nov;14(11):1762-5. PMID: 18976565

Bat-Borne Viral Diseases. Jean Paul Gonzalez, Meriadeg Ar Gouilh, Jean-Marc Reynes and Eric Leroy. Chapter 8 in Carol J. Pierce Colfer and Eckhard Kleinau, eds. Human Health and Forests. A Global Overview of Issues, Practice and Policy. 2008.

Fundamentals, domains and diffusion of disease emergence : tools and strategies for a new paradigm. Gonzalez Jean-Paul, Barbazan Philippe, Baillon F., Capelle J., Chevallier D., Cornet Jean-Paul, Fournet Florence, Herbreteau Vincent, Hugot Jean-Pierre, Le Gouilh M., Leroy Eric, Mondet Bernard, Nitatpattana N., Rican S., Salem Gérard, Tuntrapasarat W., Souris Marc. In : Tibayrenc Michel (ed.). Encyclopedia of infectious diseases : modern methodologies. Hoboken : J. Wiley, 2007, p. 525-568.

Research Skills:

  • Field experience – Survey sampling design and implementation: Intensive experience conducting fieldwork and sample collection in temperate and tropical regions (mainly Europe and Asia); Naturalist : > 20 years experience in identifying mammals, birds, bats, fishes, insects and plants from Europe (4 years for Asia); > 10 years experience in the use of field techniques for catching insects and mammals.
  • Lab skills – Extensive experience in BSL2 & BSL3 (>5 years), design and implementation of experimental models for biosafety level 3 viruses (SARS-CoV, MERS-CoV, H5N1 …). Working experience on hemorrhagic fever agents and BSL4 (glove-box). Extensive experience with cell culture, from first explant to immortalized continuous cell-line, using various cell type of diverse origin. Extensive experience with DNA and RNA extraction, purification and specific or random amplification from diverse sources including complex matrices (organs, blood, feces …) and with pretreatment of samples for high throughput sequencing (NGS). Extensive experience in virology (viral production, titration, western-blot… ) and molecular biology, amplification of various genetic markers (e.g. viral RNA, tRNA, nuclear genes, mitochondrial DNA…) using various method including (PCR, RT-PCR, qRT-PCR and PCR-free methods). Experience with ABI 3130x genetic analyser.
  • Data analysis – Extensive experience with many programs used in statistics, genetic data manipulation, phylogenetic or selection analysis and bayesian statistics (e.g. CLC, Clustal, Seaview, Artemis, Tablet, Mega, HyPhy, BEAST suite, Modeltest, PAUP4.0, MacClade, POY …). Extensive experience analysing next generation sequencing data of various format. Familiar with, PHP MyAdmin, MySQL, SGBD (database management), office suite and Adobe suite (Illustrator, Photoshop…).

Languages:

  • French (Native),
  • English (Excellent spoken and written)
  • Spanish (Good spoken and written)
  • Thai (medium spoken)

Referees:

  • Dr. Jean-Claude MANUGUERRA, VD, PhD, Cellule d’Intervention Biologique d’Urgence (CIBU), WHOCC for reference and research on Viral Hemorrhagic Fever and Arboviruses. Environment and Infectious Risks Research and Expertise Unit. Institut Pasteur, 28 rue du dr Roux, 75724 Paris c 15. jean-claude.manuguerra@pasteur.fr Tel: +33 1 40 61 38 08. Fax:+33 1 40 61 38 07.
  • Pr. Astrid VABRET, MD, PhD, Department head, Virology, Caen University Hospithal. Head of National Reference Centre for measles and paramyxoviridae, EA4655, Microbial Risks Research Unit, U2RM, Université de Caen Normandie.  vabret-a@chu-caen.fr Tel: + 33 2 31 27 25 54. Fax: + 33 2 31 27 25 57.
  • Dr. Noël TORDO, Antiviral Strategies Unit, WHO Collaborative Centre for Arboviruses and Viral Haemorrhagic Fevers, OIE Reference Laboratory for RVFV and CCHFV, Institut Pasteur, 25 rue du Dr. Roux, 75724 – Paris – Cedex 15, France. ntordo@pasteur.fr Tel : +33(0)140613134 – Fax : +33(0)140613421.
  • Pr. Pierre-Emmanuel CECCALDI, Université Paris-Diderot, Co-head of cours de Virologie Fondamentale de l’Institut Pasteur. Epidemiology and Physiopathology of Oncogenic Viruses. CNRS UMR 3569. Institut Pasteur, 25 rue du Dr. Roux, 75724 – Paris – Cedex 15, France. emmanuel.ceccaldi@pasteur.fr Tel : +33(0)1 45 68 87 82.