Projets Projet En cours 4 Membres TopSpec : Next generation precision antibody profiling – from science fiction to reality Julia Chamot-Rooke (PI) One of the major challenges of modern medicine is to understand how the human organism defends itself against invasions and diseases. The biggest mystery is the human immune system, and understanding this ultimately requires […] Projet En cours 12 Membres Role of tubulin glutamylation in flagellum construction (TUBGLUFLA) Philippe Bastin (PI) Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […] Projet En cours 8 Membres Cross-linking Mass Spectrometry Martial Rey (PI) Covalent cross-linking combined to mass spectrometry is a powerful approach to address both the structure and composition of protein complexes. To improve the crucial stage of detection and characterization of cross-linked peptides, we have […] Projet En cours 4 Membres Top-down proteomics Julia Chamot-Rooke (PI) Top-down strategies, based on the study of entire proteins, hold great promise for structural protein analysis. Whilst the classical, bottom-up approach can be useful for locating proteins already deposited in the databases, only a […]
Publications Télécharger 2019 Lima DB, Silva ARF, Dupré M, Santos MDM, Clasen MA, Kurt LU, Aquino PF, Barbosa VC, Carvalho PC, Chamot-Rooke J, Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra, Bioinformatics 2019 Feb;.
