EDUCATION 2014 MSc “Biological Engineering” (with high honors), CNAM Paris. “Recruitment and activation of plasmacytoid dendritic cells in a mouse tumor model” Supervisors : G. Dadaglio and C. Leclerc 2001 Specialization Certificate in Molecular and Cellular Biology, AFBB Paris 9ème. 2000 BTS in Biochemistry, ESBB Paris 9ème.
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Tumor immunity and preclinical development of cancer vaccines
Claude Leclerc (PI)
Human Papillomaviruses (HPV) are the major cause of human cervical cancer. We have developed a therapeutic tumor vaccine, the CyaA-E7 vaccine, that can induce specific responses against the HPV E7 oncoprotein and eliminate E7 […]
2022c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile., Sci Signal 2022 Sep; 15(750): eabn8171.
2021Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile., ISME J 2021 Jun; (): .
2018Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells., Nat Commun. 2018 Jun 8;9(1):2241.
2018Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling., Cancer Res. 2018 Jun 1;78(11):3014-3026.
2016B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer, Int. J. Cancer 2016 Sep;139(6):1358-71.
2015Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication, Cancer Res. 2015 Aug;75(16):3279-91.
2014Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses, J. Immunol. 2014 Aug;193(4):1787-98.
2008Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442, Antimicrob. Agents Chemother. 2008 Apr;52(4):1264-8.
2007A gene expression signature associated with metastatic cells in effusions of breast carcinoma patients, Int. J. Cancer 2007 Sep;121(5):1036-46.
2003Biochemical characterization and NMR studies of the nucleotide-binding domain 1 of multidrug-resistance-associated protein 1: evidence for interaction between ATP and Trp653, Biochem. J. 2003 Dec;376(Pt 3):749-56.
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