(EN) EDUCATION 2014 MSc “Biological Engineering” (with high honors), CNAM Paris. “Recruitment and activation of plasmacytoid dendritic cells in a mouse tumor model” Supervisors : G. Dadaglio and C. Leclerc 2001 Specialization Certificate in Molecular and Cellular Biology, AFBB Paris 9ème. 2000 BTS in Biochemistry, ESBB Paris 9ème.
Cliquez pour voir le graph
Cliquez pour voir la ligne de temps
Ligne de temps
Tumor immunity and preclinical development of cancer vaccines
Claude Leclerc (PI)
Human Papillomaviruses (HPV) are the major cause of human cervical cancer. We have developed a therapeutic tumor vaccine, the CyaA-E7 vaccine, that can induce specific responses against the HPV E7 oncoprotein and eliminate E7 […]
2018Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells., Nat Commun. 2018 Jun 8;9(1):2241.
2018Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling., Cancer Res. 2018 Jun 1;78(11):3014-3026.
2016B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer, Int. J. Cancer 2016 Sep;139(6):1358-71.
2015Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication, Cancer Res. 2015 Aug;75(16):3279-91.
2014Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses, J. Immunol. 2014 Aug;193(4):1787-98.
2008Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442, Antimicrob. Agents Chemother. 2008 Apr;52(4):1264-8.
2007A gene expression signature associated with metastatic cells in effusions of breast carcinoma patients, Int. J. Cancer 2007 Sep;121(5):1036-46.
2003Biochemical characterization and NMR studies of the nucleotide-binding domain 1 of multidrug-resistance-associated protein 1: evidence for interaction between ATP and Trp653, Biochem. J. 2003 Dec;376(Pt 3):749-56.