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Natural Control of HIV-1 Infection
Asier Sáez-Cirión (PI)
HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]
2019Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection, Nat Metab 1, 704–716 (2019).
2018Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 T Cells and Offers an Opportunity to Tackle Infection, Cell Metab. 2018 Dec;.
2018Cellular Determinants of HIV Persistence on Antiretroviral Therapy, Adv. Exp. Med. Biol. 2018;1075:213-239.
2017p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity, J. Virol. 2017 Dec;91(23).
2014BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid, Retrovirology 2014;11:120.
2014Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility, Virology 2014 Jul;460-461:34-44.
2013Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1, Retrovirology 2013;10:131.
2013The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6, Retrovirology 2013;10:46.
2013The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation, Cell Host Microbe 2013 Apr;13(4):441-51.
2013Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication, Virology 2013 May;440(1):8-18.
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