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BORN : August 1965 Copenhagen – Denmark
EDUCATION :
- 2003: Habilitation (HDR) Paris University 7
- 1992-1993: Postdoctoral Fellow at the Institut Pasteur – Paris. Research Topic: Characterization of a human SWI/SNF complex. Advisor: Prof. Moshe Yaniv.
- 1992: PhD in Microbiology-Biotechnology, INSA Toulouse. Thesis: Transcriptional regulation of the human retroviruses HIV-1 and HTLV-1. Research studies were done in the laboratory of Dr Richard Gaynor at UCLA.
LABORATORIES :
- 2006-present: Head Unit. « Epigenetic Regulation » at the Institut Pasteur. Unit rated “outstanding” by the HCERES evaluation committee in February 2015.
- 1999-2006: Group leader. « Chromatin, transcription, and diseases ». CNRS unit headed by Moshe Yaniv at the Institut Pasteur.
- 1996-1999: Group leader. « Remodeling of chromatin during transcription ». CNRS unit headed by Moshe Yaniv at the Institut Pasteur.
Honors:
- Prix d’excellence académique Franco-Israélien 2008
- Lauréat AVENIR INSERM 2005
Advisory commitees
- 2010-2013: Elected member of the Scientific Evaluation Committee (COMESP) at the Institut Pasteur.
- 2006-2011: Membre de la commission d’expertise régionale « Ile de France » (CR1) de l’ARC.
- 2005-2009: Membre du conseil scientifique national de la LIGUE CONTRE LE CANCER, Président de la commission d’expertise « génétique et oncogenèse » (section 1).
- 1998-2004: Membre nommé du Comité National de la Recherche Scientifique (Section 23)
EDITORIAL ACTIVITIES
Member of the editorial board of “Epigenomics”
RESEARCH ADMINISTRATION
2012-present: Deputy Director of the Departement of Developmental and Stem Cell Biology
2006-2009: Président du Comité de Site “Fernbach-Animalerie” à l’Institut Pasteur.
NETWORKS
- Member of the LabEx ‘REVIVE’ (Stem cells)
- Member of the STEM-pôle (Ile-de-France)
- Associated with the Epigenesys Network of Excellence
Publications
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2018HIBISCUS: HYDROXYCHLOROQUINE FOR THE SECONDARY PREVENTION OF THROMBOTIC AND OBSTETRICAL EVENTS IN PRIMARY ANTIPHOSPHOLIPID SYNDROME, Autoimmun Rev 2018 Oct;.
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2018Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities?, Autoimmun Rev 2018 Aug;17(8):739-745.
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2016A Broad Set of Chromatin Factors Influences Splicing, PLoS Genet. 2016 Sep;12(9):e1006318.
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2015Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors, Oncotarget 2015 May;.
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2015Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions, Nucleic Acids Res. 2015 Feb;43(3):1869-82.
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2014The translation elongation factor eEF1A1 couples transcription to translation during heat shock response, Elife 2014;3:e03164.
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2014Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF, EMBO J. 2014 Nov;33(22):2606-22.
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2014DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression, EMBO Rep. 2014 Jun;15(6):686-94.
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2013Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription, Cell Rep 2013 Aug;4(3):601-8.
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201310-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action?, Transcription 2013 May-Jun;4(3):89-91.
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