Role of tubulin glutamylation in flagellum construction (TUBGLUFLA)
Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]
CyaA secretion, folding and translocation across membrane
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
Top-down strategies, based on the study of entire proteins, hold great promise for structural protein analysis. Whilst the classical, bottom-up approach can be useful for locating proteins already deposited in the databases, only a […]
2020Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry., J Am Soc Mass Spectrom 2020 Sep; 31(9): 1783-1802.
2020Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis., Elife 2020 Feb; 9(): .
2018Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough, Toxicon 2018 Jul;149:37-44.
2016Pseudopilin residue E5 is essential for recruitment by the type 2 secretion system assembly platform, Mol. Microbiol. 2016 09;101(6):924-41.
2015Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization, PLoS Pathog 11(12): e1005312. doi:10.1371/journal. ppat.1005312.
2015Conserved Streptococcus pneumoniae spirosomes suggest a single type of transformation pilus in competence, PLoS Pathog. 2015 Apr;11(4):e1004835.
2014Ion source parameters and hydrogen scrambling in the ECD of selectively deuterated peptides, IJMS, 2014, 367, 21:27.