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Jun 2022
2022-06-30 8:00:00 2022-06-30 18:00:00 Europe/Paris Postdoctoral position in noise exposure Offer description A postdoctoral position with 24 months of funding is available immediately for an advanced scientist in audiology, biophysics or neurosciences at the Centre for Research and Innovation in Humans (CERIAH) codirected by […] "25-28 rue du Dr. Roux, 75015, Paris" Céline Quinsac celine.quinsac@pasteur.fr

Offer description

A postdoctoral position with 24 months of funding is available immediately for an advanced scientist in audiology, biophysics or neurosciences at the Centre for Research and Innovation in Humans (CERIAH) codirected by Professor Paul Avan and Professor Hung Thai-Van at the Institut de l’Audition, Institut Pasteur, in Paris, France.

We are seeking an outstanding, highly motivated postdoctoral fellow for a project on fine characterization of auditory impairments by developing innovative electrophysiological protocols in humans and/or animal models. Depending on the areas of expertise of the candidate, psychoacoustics tests could be included in the project.

The goal of this large-scale project is to develop innovative treatments for a crucial type of hearing impairment, linked to noise exposure, in collaboration with another research institute and two industrial partners.

Institut de l’Audition and CERIAH 

The Institut de l’Audition (Hearing Institute) is an interdisciplinary research institute with the objective of promoting integrative approaches to basic auditory neuroscience, developing innovative diagnostic tools and preventive and curative treatments for hearing disabilities. The Institut de l’Audition brings together world-class researchers from various fields, including neurophysiology, computational neuroscience, auditory cognition, genetics and genomics, cell biology and gene therapy. Most teams associate fundamental researchers and MDs and conduct research protocols applicable to humans with clinicians as co-investigators.

The Institut de l’Audition, located in the centre of Paris is hosting the Centre for Research and Innovation in Humans (CERIAH), dedicated to the running of research protocols on human volunteers (excluding clinical trials for drugs). Providing a very complete set of cutting-edge equipment, dedicated staff composed of research audiologists, engineers and project manager and know-how in all the auditory science domains, the CERIAH aims to increase the understanding of hearing problems, with a view to developing personalized medicine.

Mission

The postdoctoral fellow will work on a cutting-edge project aiming to better understand the mechanisms of hearing loss and recuperation following a sound trauma.

  • First, the candidate will have to continue ongoing development of audiological in vivo techniques such as specific electrocochleography and otoacoustic emissions on animal models. These biophysical recordings will be analysed alongside biochemical and anatomic data (biomarker assays, histology),
  • In parallel, the applicant will have to adapt and normalize these techniques on human volunteers, to establish the criteria for classification into the main categories: Temporary Threshold Shift (TTS), Permanent Threshold Shift (PTS) or hidden hearing loss (i.e. undetectable by standard audiological means).
  • In addition, he/she will implement subjective methods such as speech intelligibility in noise and evaluation of suprathreshold auditory distortions to complete the auditory phenotype of the human volunteers.

Qualifications

Candidate profile:

  • A PhD in physics, biophysics, biology, neurosciences or related field is required,
  • Experience in audiology would be highly appreciated,
  • Experience or interest in animal handling or research involving the human person, ideally both,
  • Some fluency in the French language will be a plus for conducting tests on volunteers.

Candidates should be experienced in the use of at least some of the techniques mentioned. The scope of the work can be tailored according to the candidate interests and skills.

We are looking for an autonomous, passionate and friendly person.

The position will be financed for two years with possible prolongation according to performance and grant application outcomes. The project will be conducted in the beautiful city of Paris, in the brand-new Institut de l’Audition which also may provide exciting career opportunities for young talented researchers. Interested candidates should submit a CV and cover letter mentioning a few referees who might provide a letter of recommendation.

 

Starting: Beginning of 2022 preferred

Net salary: 30 000 €/y minimum, according to experience

Team: CERIAH (Prof Paul Avan), Institut de l’Audition, Institut Pasteur, 63 rue de Charenton, 75012 Paris, France. https://www.institut-audition.fr/en/articles/ceriah

Contact: Céline Quinsac (ceriah@pasteur.fr)