Séminaire du Département Mycologie
Medical Research Council Centre for Medical Mycology, University of Exeter, UK
“The fungal zincophore as a key determinant in zinc scavenging and immunopathology”
Jeudi 25 novembre 2021, 12h00
Salle Jean-Paul Aubert
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Contact : Iuliana Ene (firstname.lastname@example.org)
Our immune systems effectively prevent the vast majority of microbes from causing disease. One of the fundamental mechanisms underpinning this defence is called “nutritional immunity”.
This is a system in which the human body withholds access to certain essential trace minerals that microbes require for growth. Pathogenic microbes therefore must have evolved strategies to circumvent nutritional immunity in order to grow within their host and cause disease.
In this seminar I will talk about the fungal specific zinc scavenging system – the Pra1 zincophore. The evolution of the genes encoding this system will be discussed and I will present new data showing how the zincophore drives immunopathology during candidiasis.