Présentation
AVIS DE SOUTENANCE
UNIVERSITÉ DE VERSAILLES SAINT-QUENTIN-EN-YVELINES
Anne Marie WEHENKEL
autorisée à présenter ses travaux en vue de l’obtention de l’Habilitation à Diriger des Recherches à l’Université de Versailles Saint-Quentin-en-Yvelines en Microbiologie Structurale:
« Molecular mechanisms of corynebacterial cell division and elongation »
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MEMBRES DU JURY
M. Jean-Louis HERRMANN, Professeur des Université-Praticien Hospitalier, Université de Versailles Saint-Quentin-en-Yvelines – Rapporteur
M. Alain BAULARD, Directeur de Recherche INSERM, Institut Pasteur de Lille – Rapporteur
M. Mohammed TERRAK, Chercheur Qualifié FNRS, Centre d’Ingénierie de Protéines, Université de Liège – Rapporteur
M. Benoît GIGANT, Directeur de Recherche CNRS, Institut de Biologie Intégrative de la Cellule (I2BC), Gif-sur-Yvette – Examinateur
Mme. Dorit HANEIN, Directrice de Recherche, Institut Pasteur, Paris – Examinatrice
Abstract:
Bacterial cell division is a highly regulated process, coordinated by a multi-protein complex called the divisome. The assembly of the divisome is initiated by FtsZ, the bacterial tubulin homologue, which polymerizes to form a Z-ring at the future site of septation. Subsequently, late divisomal proteins are recruited in a largely linear hierarchy to assemble the complex transmembrane machinery required for septal cell wall remodeling, constriction and final separation of the daughter cells. The molecular mechanisms of this assembly and their regulation remain largely unknown, especially in Corynebacteriales, a bacterial suborder comprising important human pathogens such as, Mycobacterium tuberculosis and Corynebacterium diphtheriae. The main objective of my work is to identify and characterize the protein-protein interactions involved in the assembly and regulation of the division machinery in Corynebacteriales using an integrative biology approach, ranging from structural biology to bacterial genetics and cellular biology.