“ Daddy issues: effects of the paternal environment on the next generation in mammals. ”
Invited Speaker: Dr. Ollie Rando
UMass Medical School, Biochemistry and Molecular Pharmacology laboratory,
Worcester, Massachussetts, USA
Summary: It is increasingly clear that environmental conditions experiences in one generation can affect phenotypes in future generations. In mammals, we have focused on effects of paternal exposure history on a variety of traits in his children. I will discuss our ongoing work to understand how paternal dietary history is transmitted to offspring, focusing on 1) surprising aspects of small RNA biogenesis in the male reproductive tract; 2) effects of tRNA fragments on preimplantation gene regulation; and 3) the “bandwidth” of sperm information transfer.
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