Présentation
This conference focuses on the role of antioxidants as modulators of redox signaling pathways rather than players that counteract oxidative stress. Indeed, antioxidants affect cells signaling provided by redox processes. Mitochondria constitute localized signaling domains and produce reactive oxygen species, ROS (i.e. superoxide and hydrogen peroxide), which are signaling molecules generated by the respiratory chain. The conference will also focus on understanding the mechanisms by which cells respond to oxidative stress and prevent cell damage and cell death, with a particular interest in neurons and neurological conditions, stroke, Alzheimer’s disease, kidney, muscle, and liver pathologies. The mechanisms of redox regulation of cellular processes will also be discussed. Little is known on the specific targets of ROS and how oxidant and antioxidant signals are transmitted in the cell. To understand mechanisms of redox control and their role in oxidative stress pathologies and aging, it is necessary to identify and dissect the function of the key players of redox processes.
We aim that Paris Redox 2016 will contribute to a better understanding of redox control in physiological and pathological states and in ageing, leading to new therapeutic and disease-preventive agents.