UPR-Laboratory of neurobiology Biology and biotherapies of myopathies Ecole Nationale Vétérinaire d’Alfort 7, avenue du Général de Gaulle 94704 Maisons-Alfort Tel +331 4396 7171/7047 Fax +331 4396 7089 sblot@vet-alfort.fr Laboratory Website Our objective is to demonstrate in a large animal model of inherited degenerative myopathies the relevance of potential cell therapies for human application. To achieve this aim, we use spontaneous canine myopathies that finely mimick the human situation. The biological effects of promising muscle progenitors (like mesoangioblasts) delivered intra-arterially with routine procedures after specific conditioning (for allogeneic cells with immune suppression or for autologous cells) are demonstrated by multiparametric biomarkers using transposable methods to patients.
École nationale vétérinaire d'Alfort - EnvA, Avenue du Général de Gaulle, Maisons-Alfort, France
