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© Research
Institut Pasteur

Milieu Intérieur (MI) approach to study variability in SARS-CoV-2 immune response funded by ANR

Published on 28 Apr 2020

James Di Santo and Darragh Duffy (MI co-coordinator) – have been funded by the French National Research Agency (ANR) to study variability in the SARS-COV-2 immune response. The project entitled “Systemic and mucosal immune response variation during SARS-CoV-2 infection and recovery” (CoVarImm) will work on one of the 4 priority areas identified by the World Health Organisation to combat COVID19.

As a response to the COVID19 crisis, the ANR launched the Flash ANR COVID19 call to mobilize scientific communities, expedite information on this novel and deadly coronavirus and mount a rapid and efficient response. This call was aimed at examining ideas, actions, innovations in all areas and thus have an accelerated impact on the situation. The immune response to SARS-CoV-2 is the primary cause of the lung pathology and associated morbidities leading to death in a substantial proportion of infected individuals, but this response is highly variable. There is limited knowledge of the kinetics, intensity and diversity of cellular and humoral immune responses following SARS-CoV-2 infection. Using the Milieu Intérieur cohort approach, the CoVarImm study will characterise systemic as well as local nasal mucosal innate and adaptive immune responses during and after SARS-CoV-2 infection. This will facilitate the identification of immune signatures and potential environmental and/or host factors that can distinguish clinical outcomes in COVID-19 patients. The CoVarImm project has the potential to impact on several key clinical decision making choices in the management of COVID-19 patients.

They aim to work together with the scientific community and will share results and data as soon as they are available and contribute towards combating COVID19.

Check our twitter account and website for updates.

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