Timeline

François Spitz
Head of Structure
17 Jan 2018
publication

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

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04 Oct 2017
event

Mini Symposium and Workshop – Single cell @ Pasteur

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27 Sep 2017
publication

Two independent modes of chromatin organization revealed by cohesin removal

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23 Jun 2017
project

Pasteur Single Cell Initiative

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05 Dec 2016
publication

The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances

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05 Oct 2016
publication

Formation of new chromatin domains determines pathogenicity of genomic duplications

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27 Jun 2016
publication

Gene regulation at a distance: from remote enhancers to 3D regulatory ensembles

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11 Apr 2016
publication

Cis-regulatory architecture of a brain signaling center predates the origin of chordates

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12 Nov 2015
publication

Gene regulation during development in the light of topologically associating domains

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28 Oct 2015
team

Genomics and Epigenomics of Animal Development

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22 May 2015
publication

Model mice for 15q11-13 duplication syndrome exhibit late-onset obesity and altered lipid metabolism

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29 Jan 2015
publication

Hoxa2 selectively enhances Meis binding to change a branchial arch ground state

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08 Jan 2015
publication

A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes

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05 Jun 2014
publication

The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains

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25 May 2014
publication

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis

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07 Jan 2014
publication

Functional and topological characteristics of mammalian regulatory domains

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18 Sep 2013
publication

Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase

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01 Jun 2013
publication

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

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06 May 2013
publication

From remote enhancers to gene regulation: charting the genome’s regulatory landscapes

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02 Apr 2013
publication

TRACER: a resource to study the regulatory architecture of the mouse genome

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28 Feb 2013
publication

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape

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01 Feb 2013
publication

Phenotypic impact of genomic structural variation: insights from and for human disease

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07 Aug 2012
publication

Transcription factors: from enhancer binding to developmental control

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23 Nov 2011
publication

A regulatory archipelago controls Hox genes transcription in digits

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20 Mar 2011
publication

Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor

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29 Dec 2010
publication

A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus

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14 Jan 2010
publication

KAP1 controls endogenous retroviruses in embryonic stem cells

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01 Jan 2010
publication

Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences

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06 Mar 2009
publication

Uncoupling time and space in the collinear regulation of Hox genes

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16 Dec 2008
publication

Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences

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07 May 2008
publication

Genotypic features of lentivirus transgenic mice

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05 Apr 2008
publication

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3

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01 Jan 2008
publication

Global control regions and regulatory landscapes in vertebrate development and evolution

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23 Mar 2007
publication

Transgenic analysis of Hoxd gene regulation during digit development

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03 Jul 2005
publication

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes

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01 Jul 2004
publication

Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype

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15 Jun 2004
publication

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

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01 May 2003
publication

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

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01 Oct 2002
publication

Fiber-type specific and position-dependent expression of a transgene in limb muscles

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01 Apr 2002
publication

A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects

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01 Sep 2001
publication

Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations

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13 Oct 2000
publication

The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins

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18 Jun 1999
publication

Developmental regulation of the aldolase A muscle-specific promoter during in vivo muscle maturation is controlled by a nuclear receptor binding element

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24 Nov 1998
publication

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

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12 Jun 1998
publication

Proximal sequences of the aldolase A fast muscle-specific promoter direct nerve- and activity-dependent expression in transgenic mice

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01 Mar 1998
publication

The human pH aldolase A promoter directs widespread but muscle-predominant expression in transgenic mice

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01 Jan 1998
publication

A binding site for nuclear receptors is required for the differential expression of the aldolase A fast-twitch muscle promoter in body and head muscles

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01 Feb 1997
publication

A combination of MEF3 and NFI proteins activates transcription in a subset of fast-twitch muscles

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13 Oct 1995
publication

Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site (M1) for unknown proteins

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