Timeline

Jean-Paul Latge

Head of Structure

15 Feb 2023

publication

The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus.

24 Jan 2023

publication

Conidium Specific Polysaccharides in Aspergillus fumigatus.

18 May 2021

publication

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus.

06 Jan 2021

publication

Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring.

12 Aug 2020

publication

Characterization of Extracellular Vesicles Produced by Aspergillus fumigatus Protoplasts.

01 Jan 2020

publication

GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis.

01 Dec 2019

publication

Assembly and disassembly of Aspergillus fumigatus conidial rodlets

30 Aug 2019

publication

Aspergillus fumigatus exoβ(1-3)glucanases family GH55 are essential for conidial cell wall morphogenesis

21 Jul 2017

publication

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

13 Apr 2017

event

“Lymphocyte development and lineage commitment in the embryo” by Ana Cumano

23 Mar 2017

event

“Vascular colonization by Neisseria meningitidis” by Guillaume Duménil

17 Mar 2017

news

Conferences organized by the Scientific Council – 2017

11 Jul 2016

publication

Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.

15 Jun 2016

publication

GH16 and GH81 family β-(1,3)-glucanases in Aspergillus fumigatus are essential for conidial cell wall morphogenesis

30 Mar 2016

publication

Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease

15 Mar 2016

publication

Volatile Compounds Emitted by Pseudomonas aeruginosa Stimulate Growth of the Fungal Pathogen Aspergillus fumigatus

01 Mar 2016

publication

Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer

12 Feb 2016

publication

Mucorales-Specific T Cells in Patients with Hematologic Malignancies

31 Dec 2015

publication

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

24 Dec 2015

publication

The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi

06 Oct 2015

project

COMASPIN

28 Sep 2015

publication

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus

26 Aug 2015

publication

Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus

01 Aug 2015

publication

Aspergillus Biofilm In Vitro and In Vivo

11 May 2015

department

Mycology

01 Apr 2015

publication

(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus

25 Mar 2015

publication

Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets

27 Feb 2015

publication

Targeting zinc homeostasis to combat Aspergillus fumigatus infections

10 Feb 2015

publication

Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines

06 Feb 2015

publication

Fungal immunology: from simple to very complex concepts

30 Jan 2015

publication

Hybrid histidine kinases in pathogenic fungi

30 Dec 2014

publication

Aspergillus fumigatus devoid of cell wall β-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors

06 Nov 2014

publication

Aspergillus fumigatus and related species

05 Nov 2014

publication

Synthesis of a pentasaccharide and neoglycoconjugates related to fungal α-(1→3)-glucan and their use in the generation of antibodies to trace Aspergillus fumigatus cell wall

15 Aug 2014

publication

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

25 Jul 2014

publication

Editorial overview: Host-microbe interactions: fungi

20 Jun 2014

publication

Aspergillus cell wall and biofilm

14 Jun 2014

publication

Functional duality of the cell wall

06 Jun 2014

publication

The volatome of Aspergillus fumigatus

13 May 2014

publication

Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice

12 May 2014

publication

Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response

30 Apr 2014

publication

A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells

07 Apr 2014

publication

Immunosuppressive compounds exhibit particular effects on functional properties of human anti-Aspergillus Th1 cells

13 Mar 2014

publication

Chemical organization of the cell wall polysaccharide core of Malassezia restricta

12 Mar 2014

publication

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence

06 Mar 2014

publication

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist

20 Nov 2013

publication

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides

14 Nov 2013

publication

Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus

10 Oct 2013

publication

Oh, to be new

04 Sep 2013

publication

Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients

22 Aug 2013

publication

Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system

07 Aug 2013

publication

The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo

16 Jul 2013

publication

Unraveling the nanoscale surface properties of chitin synthase mutants of Aspergillus fumigatus and their biological implications

06 May 2013

publication

No effect of antifungal compounds on functional properties of human antifungal T-helper type 1 cells

17 Apr 2013

publication

β-1,3-glucan modifying enzymes in Aspergillus fumigatus

05 Apr 2013

publication

Pathway of glycine betaine biosynthesis in Aspergillus fumigatus

18 Mar 2013

publication

SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis

06 Mar 2013

publication

Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp

01 Mar 2013

publication

Clinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes

12 Feb 2013

publication

Investigation of Aspergillus fumigatus biofilm formation by various “omics” approaches

01 Feb 2013

publication

Circulating human basophils lack the features of professional antigen presenting cells

01 Jan 2013

publication

Undressing the fungal cell wall/cell membrane–the antifungal drug targets

04 Dec 2012

publication

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

01 Dec 2012

publication

The diverse applications of RNA-seq for functional genomic studies in Aspergillus fumigatus

30 Nov 2012

publication

High-resolution imaging of chemical and biological sites on living cells using peak force tapping atomic force microscopy

10 Sep 2012

publication

Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins

18 Jun 2012

publication

Fungal antioxidant pathways promote survival against neutrophils during infection

31 May 2012

publication

Hydrophobins–unique fungal proteins

23 Apr 2012

publication

CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

05 Mar 2012

publication

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

21 Feb 2012

publication

Sensing of mammalian IL-17A regulates fungal adaptation and virulence

07 Feb 2012

publication

Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6

28 Jan 2012

publication

A novel dehydrin-like protein from Aspergillus fumigatus regulates freezing tolerance

10 Jan 2012

publication

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

14 Dec 2011

publication

Prospective evaluation of clinical and biological markers to predict the outcome of invasive pulmonary aspergillosis in hematological patients

06 Dec 2011

publication

TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

10 Nov 2011

publication

Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus

04 Nov 2011

publication

α1,3 glucans are dispensable in Aspergillus fumigatus

20 Oct 2011

publication

HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus

01 Jul 2011

publication

Global transcriptome changes underlying colony growth in the opportunistic human pathogen Aspergillus fumigatus

20 May 2011

publication

Phylogenetic and functional analysis of Aspergillus fumigatus MGTC, a fungal protein homologous to a bacterial virulence factor

13 Apr 2011

publication

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus

01 Aug 2010

publication

Comparative functional analysis of the OCH1 mannosyltransferase families in Aspergillus fumigatus and Saccharomyces cerevisiae

07 Jul 2010

publication

Characterization of the GPI-anchored endo β-1,3-glucanase Eng2 of Aspergillus fumigatus

11 Jun 2010

publication

beta(1-3)Glucanosyltransferase Gel4p is essential for Aspergillus fumigatus

06 May 2010

publication

Tasting the fungal cell wall

04 May 2010

publication

Cell wall alpha1-3glucans induce the aggregation of germinating conidia of Aspergillus fumigatus

01 May 2010

publication

Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia

14 Apr 2010

publication

Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability

01 Feb 2010

publication

Functional analysis of the superoxide dismutase family in Aspergillus fumigatus

30 Nov 2009

publication

Characterization of a new beta(1-3)-glucan branching activity of Aspergillus fumigatus

04 Nov 2009

publication

In vivo biofilm composition of Aspergillus fumigatus

27 Aug 2009

publication

Surface hydrophobin prevents immune recognition of airborne fungal spores

19 Aug 2009

publication

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors

03 Aug 2009

publication

Characterization of glucuronic acid containing glycolipid in Aspergillus fumigatus mycelium

26 Jun 2009

publication

Galactofuranose attenuates cellular adhesion of Aspergillus fumigatus

01 Jun 2009

publication

Aspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organization

11 Mar 2009

publication

Cell wall beta-(1,6)-glucan of Saccharomyces cerevisiae: structural characterization and in situ synthesis

21 Jan 2009

publication

Characterization of a biofilm-like extracellular matrix in FLO1-expressing Saccharomyces cerevisiae cells

16 Sep 2008

publication

Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia

14 Aug 2008

publication

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway

05 Aug 2008

publication

Galactofuranose containing molecules in Aspergillus fumigatus

30 Oct 2007

publication

Glycosylinositolphosphoceramides in Aspergillus fumigatus

14 Sep 2007

publication

The cell wall: a carbohydrate armour for the fungal cell

16 Feb 2007

publication

An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus

02 Feb 2007

publication

Testing the efficacy of RNA interference constructs in Aspergillus fumigatus

30 Jan 2007

publication

Characterization of the SKN7 ortholog of Aspergillus fumigatus

15 Sep 2006

publication

Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4

01 May 2006

publication

Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus

19 Apr 2006

publication

Recombinant antigens as diagnostic markers for aspergillosis

04 Oct 2005

publication

Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus

01 Sep 2005

publication

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis

01 Aug 2005

publication

Aspergillus fumigatus: saprophyte or pathogen?

01 Jun 2005

publication

Deletion of GEL2 encoding for a beta(1-3)glucanosyltransferase affects morphogenesis and virulence in Aspergillus fumigatus

01 Jan 2005

publication

Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis

01 Jan 2005

publication

Chitinases and peptide mimotopes

01 Dec 2004

publication

In vitro biosynthesis of glycosylphosphatidylinositol in Aspergillus fumigatus

15 Aug 2004

publication

Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus

01 Jun 2003

publication

Catalases of Aspergillus fumigatus

01 Mar 2003

publication

Conidial hydrophobins of Aspergillus fumigatus

30 Oct 2002

publication

Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins

01 Sep 2002

publication

Characterization of a cell-wall acid phosphatase (PhoAp) in Aspergillus fumigatus

01 Jul 2002

publication

Characterization of essential genes by parasexual genetics in the human fungal pathogen Aspergillus fumigatus: impact of genomic rearrangements associated with electroporation of DNA

A little guide for advanced search:

The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus.

Conidium Specific Polysaccharides in Aspergillus fumigatus.

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus.

Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring.

Characterization of Extracellular Vesicles Produced by Aspergillus fumigatus Protoplasts.

GPI Anchored Proteins in Aspergillus fumigatus and Cell Wall Morphogenesis.

Assembly and disassembly of Aspergillus fumigatus conidial rodlets

Aspergillus fumigatus exoβ(1-3)glucanases family GH55 are essential for conidial cell wall morphogenesis

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

“Lymphocyte development and lineage commitment in the embryo” by Ana Cumano

“Vascular colonization by Neisseria meningitidis” by Guillaume Duménil

Conferences organized by the Scientific Council – 2017

Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.

GH16 and GH81 family β-(1,3)-glucanases in Aspergillus fumigatus are essential for conidial cell wall morphogenesis

Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease

Volatile Compounds Emitted by Pseudomonas aeruginosa Stimulate Growth of the Fungal Pathogen Aspergillus fumigatus

Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer

Mucorales-Specific T Cells in Patients with Hematologic Malignancies

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi

COMASPIN

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus

Nanoscale biophysical properties of the cell surface galactosaminogalactan from the fungal pathogen Aspergillus fumigatus

Aspergillus Biofilm In Vitro and In Vivo

Mycology

(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus

Identification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets

Targeting zinc homeostasis to combat Aspergillus fumigatus infections

Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines

Fungal immunology: from simple to very complex concepts

Hybrid histidine kinases in pathogenic fungi

Aspergillus fumigatus devoid of cell wall β-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors

Aspergillus fumigatus and related species

Synthesis of a pentasaccharide and neoglycoconjugates related to fungal α-(1→3)-glucan and their use in the generation of antibodies to trace Aspergillus fumigatus cell wall

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

Editorial overview: Host-microbe interactions: fungi

Aspergillus cell wall and biofilm

Functional duality of the cell wall

The volatome of Aspergillus fumigatus

Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice

Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response

A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells

Immunosuppressive compounds exhibit particular effects on functional properties of human anti-Aspergillus Th1 cells

Chemical organization of the cell wall polysaccharide core of Malassezia restricta

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides

Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus

Oh, to be new

Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients

Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system

The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo

Unraveling the nanoscale surface properties of chitin synthase mutants of Aspergillus fumigatus and their biological implications

No effect of antifungal compounds on functional properties of human antifungal T-helper type 1 cells

β-1,3-glucan modifying enzymes in Aspergillus fumigatus

Pathway of glycine betaine biosynthesis in Aspergillus fumigatus

SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis

Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp

Clinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes

Investigation of Aspergillus fumigatus biofilm formation by various “omics” approaches

Circulating human basophils lack the features of professional antigen presenting cells

Undressing the fungal cell wall/cell membrane–the antifungal drug targets

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

The diverse applications of RNA-seq for functional genomic studies in Aspergillus fumigatus

High-resolution imaging of chemical and biological sites on living cells using peak force tapping atomic force microscopy

Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins

Fungal antioxidant pathways promote survival against neutrophils during infection

Hydrophobins–unique fungal proteins

CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

Sensing of mammalian IL-17A regulates fungal adaptation and virulence

Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6

A novel dehydrin-like protein from Aspergillus fumigatus regulates freezing tolerance

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

Prospective evaluation of clinical and biological markers to predict the outcome of invasive pulmonary aspergillosis in hematological patients

TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus

α1,3 glucans are dispensable in Aspergillus fumigatus

HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus