Timeline

Antonio Freitas
Retired scientist
07 Sep 2015
project

ERC-2009-AdG QSIS

Read more
13 Oct 2014
publication

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

Read more
27 Jun 2014
publication

Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice

Read more
31 Dec 2013
publication

A mathematical perspective on CD4(+) T cell quorum-sensing

Read more
18 Nov 2013
publication

IL-2 coordinates IL-2-producing and regulatory T cell interplay

Read more
05 Aug 2013
publication

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

Read more
14 Jul 2013
publication

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Read more
03 Dec 2012
publication

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

Read more
25 May 2012
publication

Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model

Read more
09 Apr 2012
publication

Humanized mice: current states and perspectives

Read more
14 Mar 2011
publication

Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools

Read more
29 Apr 2010
publication

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection

Read more
16 Apr 2010
publication

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

Read more
01 May 2009
publication

The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool

Read more
01 Feb 2009
publication

Homeostasis of naive T cells: the Foxo that fixes

Read more
31 Oct 2008
publication

Wild-derived mouse strains, a valuable model to study B cell responses

Read more
01 Apr 2008
publication

TLR-activated B cells suppress T cell-mediated autoimmunity

Read more
01 Jan 2008
publication

Peritoneal B-cell subsets in the genus Mus: their role in innate immunity

Read more
15 Jun 2007
publication

Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6

Read more
20 Sep 2006
publication

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

Read more
01 Jul 2006
publication

Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells

Read more
12 Jun 2006
publication

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity

Read more
01 Dec 2005
publication

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens

Read more
21 Oct 2005
publication

IPEX and FOXP3: clinical and research perspectives

Read more
17 Oct 2005
publication

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

Read more
18 Jul 2005
publication

Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation

Read more
01 Jun 2005
publication

Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells

Read more
01 Mar 2005
publication

In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects

Read more
01 Feb 2005
publication

Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation

Read more
27 May 2004
publication

Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation

Read more
15 Mar 2004
publication

Positive selection of B cells expressing low densities of self-reactive BCRs

Read more
01 Feb 2004
publication

B-cell homeostasis, competition, resources, and positive selection by self-antigens

Read more
01 Nov 2002
publication

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

Read more
01 Apr 2002
publication

Introduction: regulation of lymphocyte homeostasis

Read more
01 Dec 2001
publication

CD8+ T lymphocytes in double alpha beta TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen

Read more
01 Dec 2001
publication

CD8+ T lymphocytes in double alpha beta TCR transgenic mice. II. Competitive fitness of dual alpha beta TCR CD8+ T lymphocytes in the peripheral pools

Read more
01 Oct 2001
publication

Resource competition determines selection of B cell repertoires

Read more
01 Sep 2001
publication

T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors

Read more
01 Feb 2001
publication

Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice

Read more
01 Aug 2000
publication

Peripheral B cell survival

Read more
01 Aug 2000
publication

B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools

Read more
01 Jan 2000
publication

Considerations on B cell homeostasis

Read more
01 Jan 2000
publication

Population biology of lymphocytes: the flight for survival

Read more
01 Apr 1999
publication

Peripheral T cell survival

Read more
18 Jan 1999
publication

Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population

Read more
01 Sep 1998
publication

The role of the B cell receptor V region in peripheral B cell survival

Read more
01 Dec 1997
publication

Lymphocyte homeostasis

Read more
26 Sep 1997
publication

Lymphocyte survival: a red queen hypothesis

Read more
01 Jul 1997
publication

Independent homeostatic regulation of B cell compartments

Read more
27 Jun 1997
publication

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

Read more
27 May 1997
publication

Resource competition as a mechanism for B cell homeostasis

Read more
01 Nov 1996
publication

Cellular competition modulates survival and selection of CD8+ T cells

Read more
01 Jun 1996
publication

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes

Read more
01 Nov 1995
publication

Persistence of V beta 6+ T cells in Mls-1a mice. A role for the third complementarity-determining region (CDR3) of the T cell receptor beta chain in superantigen recognition

Read more
01 Jun 1995
publication

The role of cellular competition in B cell survival and selection of B cell repertoires

Read more
01 May 1995
publication

Lymphocytes in a model ecosystem

Read more
01 Mar 1995
publication

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance

Read more
01 Jun 1994
publication

Observations on the mode of action of normal immunoglobulin at high doses

Read more
01 Jun 1994
publication

Regulation of VH-gene expression is a lineage-specific developmental marker

Read more
01 Feb 1994
publication

Positive and negative selection of antibody repertoires during B-cell differentiation

Read more
01 Feb 1994
publication

VH-gene family dominance in ageing mice

Read more
01 Jun 1993
publication

V region dependent selection of persistent resting peripheral B cells in normal mice

Read more
01 May 1993
publication

The physiology of bcl-2 expression in murine B lymphocytes

Read more
01 Jan 1993
publication

Analysis of VH gene utilisation in the non-obese diabetic mouse

Read more
01 Jan 1993
publication

Lymphocyte lifespans: homeostasis, selection and competition

Read more
01 Oct 1992
publication

On the origin of natural IgM in immunoglobulin transgenic mice

Read more
01 Jun 1992
publication

Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice

Read more
01 Jan 1992
publication

Expression and selection of murine antibody repertoires

Read more
01 Dec 1991
publication

Clonal analysis of B lymphocyte responses to Plasmodium chabaudi infection of normal and immunoprotected mice

Read more
01 Sep 1991
publication

Clonal persistence of B lymphocytes in normal mice is determined by variable region-dependent selection

Read more
01 Jul 1991
publication

Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires

Read more
01 May 1991
publication

Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells

Read more
01 Jan 1991
publication

Endogenous VH gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires

Read more
01 Nov 1990
publication

Transfer of T or CD8+ cells from hemorrhaged mice produce alterations in bacterial antigen specific plasma cell repertoires in normal syngeneic recipients

Read more
01 Oct 1990
publication

Selection of anti-F protein B-cell repertoires in normal mice

Read more
01 Sep 1990
publication

Immunoglobulin VH gene expression following hemorrhage

Read more
01 Aug 1990
publication

Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes

Read more
01 May 1990
publication

VH gene family repertoires of “viable motheaten” (mev) mice

Read more
15 Mar 1990
publication

Purification and characterization of intraparenchymal lung lymphocytes

Read more
01 Jan 1990
publication

Population kinetics of peritoneal LPS-reactive B lymphocytes

Read more
01 Jan 1990
publication

Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development

Read more
01 Aug 1989
publication

Hemorrhage in mice produces alterations in B cell repertoires

Read more
01 Jun 1989
publication

Immunoglobulin VH gene expression in Ly-1+ and conventional B lymphocytes

Read more
01 Jun 1989
publication

Interleukin 2 receptor expression and interleukin 2 production in exponentially growing T cells: major differences between in vivo and in vitro proliferating T lymphocytes

Read more
01 Mar 1989
publication

Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity

Read more
01 Feb 1989
publication

Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation

Read more
01 Jan 1989
publication

Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment

Read more
01 Jan 1989
publication

Selection of lymphocyte repertoires: the limits of clonal versus network organization

Read more
01 Jan 1989
publication

Selection of antibody repertories: transfer of mature T lymphocytes modifies VH gene family usage in the actual and available B cell repertories of athymic mice

Read more
01 Jan 1989
publication

Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment

Read more
15 Dec 1988
publication

Effects of surgical stress on lymphoid populations of mice

Read more
01 Dec 1988
publication

Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments

Read more
01 Sep 1988
publication

Secondary antibody responses to thymus-independent antigens. Decline and life-span of memory

Read more
01 Sep 1988
publication

Long-lasting thymus-independent immune responses to anti-idiotype lipopolysaccharide conjugates require continuous B cell renewal

Read more
15 Jun 1988
publication

Selection of antibody repertoires by anti-idiotypes can occur at multiple steps of B cell differentiation

Read more
01 Jun 1987
publication

The majority of “natural” immunoglobulin-secreting cells are short-lived and the progeny of cycling lymphocytes

Read more
01 May 1987
publication

Altered fatty acid membrane composition modifies lymphocyte localization in vivo

Read more
01 Nov 1986
publication

Effects of hydroxyurea in vivo treatment on the antibody response in mice

Read more
01 Oct 1986
publication

Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation

Read more
01 Jul 1986
publication

Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice

Read more
01 Jul 1986
publication

Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice

Read more
01 Mar 1986
publication

The effects of lymph on lymphocyte migration in vivo

Read more
01 Jan 1986
publication

Two major classes of mitogen-reactive B lymphocytes defined by life span

Read more
01 Jan 1986
publication

Life span of B lymphocytes: the experimental basis for conflicting results

Read more
01 Nov 1984
publication

Lymphocytes migration into membrane filters: divergent effects of syngeneic mouse serum and lymph

Read more
01 Apr 1984
publication

Effects of hydroxyurea on concanavalin-A-induced T-cell proliferation. Depletion of T-cell growth factor-reactive and -producing T lymphocytes

Read more
01 Apr 1984
publication

Lymphocyte migration into collagen gels: role of lymph

Read more
01 Nov 1983
publication

Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs

Read more
01 Jul 1983
publication

From the mechanisms of lymphocyte activation to internal activity in the immune system

Read more
01 May 1982
publication

Spleen lymphocyte populations in patients with Hodgkin’s disease–properties of cells with different densities

Read more
01 Jan 1982
publication

Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs

Read more
01 Sep 1981
publication

Very rapid decay of mature B lymphocytes in the spleen

Read more
01 Dec 1980
publication

Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells

Read more
01 Oct 1980
publication

Characterization of mouse thoracic duct B lymphocytes. I. Evidence of functional heterogeneity

Read more
01 Apr 1979
publication

Characterization of rat spleen-cell populations. I. Cell interactions in the regulation of in vitro response to concanavalin A

Read more
15 Feb 1979
publication

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

Read more
01 Feb 1979
publication

The role of locomotion in lymphocyte migration

Read more
01 Oct 1978
publication

Effects of solute-coupled transport on lymph flow and oncotic pressures in cat ileum

Read more
01 Jun 1978
publication

[Osteogenic sarcoma in an 8-year-old girl]

Read more
01 Jan 1978
publication

Divergent actions of monomeric, dimeric, and tetrameric concanavalin A on lymphocyte traffic

Read more
22 Dec 1977
publication

Murine mesenteric and peripheral lymph nodes: a common pool of small T cells

Read more
01 Jun 1977
publication

Control mechanism of lymphocyte traffic. A study of the action of two sulfated polysaccharides on the distribution of 51Cr- and [3H]adenosine-labeled mouse lymph node cells

Read more
01 Oct 1976
publication

Control mechanism of lymphocyte traffic. Altered migration of 51Cr-labeled mouse lymph node cells pretreated in vitro with phospholipases

Read more
01 Apr 1976
publication

Control mechanism of lymphocyte traffic. Altered distribution of 51Cr-labeled mouse lymph node cells pretreated in vitro with lipopolysaccharide

Read more
15 Mar 1976
publication

The role of cell interactions in the control of lymphocyte traffic

Read more
01 Feb 1976
publication

Factors which determine the accumulation of immunoblasts in gut and skin

Read more
01 Jan 1976
publication

Role of prostaglandins (PGs) in the control of adenohypophyseal hormone secretion

Read more