Timeline

Bernard Lagane
Permanent Researcher
30 Jul 2016
publication

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions

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03 Jul 2015
project

Viral Pathogenesis Unit’s Project

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18 Jun 2015
publication

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity

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22 May 2014
publication

Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry

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21 May 2013
publication

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

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30 Apr 2013
publication

β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6

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01 Jan 2013
publication

Modeling the allosteric modulation of CCR5 function by Maraviroc

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11 Jul 2012
publication

CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity

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20 Jul 2011
publication

Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5)

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30 Nov 2010
publication

New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection

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20 Apr 2009
publication

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

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01 Aug 2008
publication

Cholesterol content drives distinct pharmacological behaviours of micro-opioid receptor in different microdomains of the CHO plasma membrane

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02 Jul 2008
publication

The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins

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13 Jun 2008
publication

Small neutralizing molecules to inhibit actions of the chemokine CXCL12

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24 Apr 2008
publication

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

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01 Mar 2008
publication

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

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13 Sep 2007
publication

CD4 interacts constitutively with multiple CCR5 at the plasma membrane of living cells. A fluorescence recovery after photobleaching at variable radii approach

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29 Dec 2006
publication

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation

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11 Oct 2006
publication

CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach

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17 Aug 2005
publication

The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

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10 Mar 2005
publication

Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis

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15 Dec 2004
publication

CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes

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09 Nov 2004
publication

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

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03 Aug 2004
publication

Dynamic confinement of NK2 receptors in the plasma membrane. Improved FRAP analysis and biological relevance

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12 Nov 2002
publication

HIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, raft membrane domains

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23 Jan 2002
publication

Lateral distribution of cholesterol in membranes probed by means of a pyrene-labelled cholesterol: effects of acyl chain unsaturation

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14 Sep 2001
publication

Probing the lateral organization of membranes: fluorescence repercussions of pyrene probe distribution

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27 Oct 2000
publication

Role of sterols in modulating the human mu-opioid receptor function in Saccharomyces cerevisiae

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