Our research is mainly dedicated to understanding the function of bio-macromolecules such as proteins, nucleic acids and oligosaccharides through the study of their structures, interactions and dynamics. To this end, we use NMR, biophysical and biochemical techniques and work in collaboration with various groups from the Institut Pasteur and with laboratories in France and abroad.
The main projects currently being undertaken in our laboratory are:
- Structural and functional studies of proteins involved in the active transport of nutrients in bacteria;
- Structure and assembly of bacterial pili
- The control of neuronal death and survival by the rabies virus glycoprotein;
- PDZ mediated viral perturbation of infected cells signaling pathways;
- Function of whirlin in the mecanoelectric transduction in the internal ear;
- Functional amyloids, structure and biosynthesis of the cell wall of the fungal pathogen Aspergillus fumigatus.