Vaccination is one of the most successful tools for controlling infectious diseases. Although it is generally perceived as the “golden solution” , it has recently been shown that the extensive use of vaccines may lead to undesirable effects (e.g. poliomyelitis epidemics due to vaccine-derived viruses) or the resurgence of a disease and its clinical characteristics as well as the development of new biological diagnosis (e.g. re-emergence of whooping cough after 40 years of vaccination). In the documented cases, epidemiological studies clearly indicate that extensive vaccinations can induce modifications of the pathogens over time, the emergence of new pathogens due to changes in the ecosystems, or change in the transmission of the disease. Therefore, to optimise the benefits of immunization programs and prevent new global adverse effects of vaccines (and the subsequent detrimental impact in the general public), the consequences of extensive vaccinations on the pathogen, ecosystem and/or human host populations remain to be evaluated.
In this context, the main objective of this unit is to evaluate the consequences of extensive vaccination in human populations, and to propose adapted strategies of prevention for children and adults and new therapeutic tools in order to face some of these consequences.
Our projects :
Links and resources of interest :
- Laboratory Manual for the diagnosis of whooping cough caused by bordetella pertussis/bordetella parapertussis WHO update 2014 .
- Guidance and protocol for the serological dg of human infection with Bordetella pertussis (ECDC 2013).
- Guidance and protocol for the use of real time PCR in lab dg of human infection with Bordetella pertussis or B. parapertussis (ECDC, 2013).
- Pertussis News : Pertussisnews is a service for those who are interested in pertussis research. This blog is regularly updated with the most recent publications and other information available on the web. Readers are invited to post their own comments and stimulate the discussion.The author of the blog is Alberto E Tozzi who is a pediatrician and an epidemiologist at the Bambino Gesù Pediatric Hospital, Rome, Italy. The blog is not supported by any vaccine manufacturers or drug companies.
- Video of Nicole Guiso, former Head of Unit
- Current approaches to the last diagnosis of Diphtheria, The Journal of Infectious Diseases – 2000
- Health – Topic : Diphtheria, WHO update
- Immunization, Vaccines and Biologicals, WHO
- Diphtheria : The Disease, WHO