Vaccination is one of the most successful tools for controlling infectious diseases. We are interested in the effects on the pathogen’s populations, of extensive vaccination programmes, as these can have several consequences:
- Modifications of the pathogen populations over time (emergence of variants that escape the immune system through the modification of the pathogen antigens that are targeted by the vaccine);
- Modifications of the microbial community carried by humans, which may favor the emergence of new pathogens;
- Changes in the transmission dynamics of the disease in the human or animal populations.
Therefore, to optimise the benefits of immunization programmes, it is important to understand the consequences of extensive vaccinations on the pathogen biology, on the microbial ecosystem, and on the human populations affected by the infection. The results contribute to the definition of optimized strategies of disease prevention.
Some of our projects are described below under the ‘projects’ header. Our unit also hosts the National Reference Centre for Whooping cough and other Bordetelloses and the National reference Centre for Corynebacteriae of the diphtheriae complex.
Some of our projects:
- Bordetella Population Biology and Vaccination
- Population biology and epidemiology of Corynebacteria
Links to related resources:
- Laboratory Manual for the diagnosis of whooping cough caused by bordetella pertussis/bordetella parapertussis WHO update 2014 .
- Guidance and protocol for the serological dg of human infection with Bordetella pertussis (ECDC 2013).
- Guidance and protocol for the use of real time PCR in lab dg of human infection with Bordetella pertussis or B. parapertussis (ECDC, 2013).
- Pertussis News : Pertussisnews is a service for those who are interested in pertussis research. This blog is regularly updated with the most recent publications and other information available on the web. Readers are invited to post their own comments and stimulate the discussion. The author of the blog is Alberto E. Tozzi who is a pediatrician and an epidemiologist at the Bambino Gesù Pediatric Hospital, Rome, Italy. The blog is not supported by any vaccine manufacturers or drug companies.
- Video on pertussis by Nicole Guiso, former Head of Unit (in French)
- Current approaches to the last diagnosis of Diphtheria, The Journal of Infectious Diseases – 2000
- Health – Topic : Diphtheria, WHO update
- Immunization, Vaccines and Biologicals, WHO
- Diphtheria : The Disease, WHO