© Nicole Guiso
Colonies hémolytiques de Bordetella pertussis sur milieu de Bordet-Gengou au sang

Molecular Prevention and Therapy of Human Diseases


Vaccination is one of the most successful tools for controlling infectious diseases. We are interested in the effects on the pathogen’s populations, of  extensive vaccination programmes, as these can have several consequences:

  • Modifications of the pathogen populations over time (emergence of variants that escape the immune system through the modification of the pathogen antigens that are targeted by the vaccine);
  • Modifications of the microbial community carried by humans, which may favor the emergence of new pathogens;
  • Changes in the transmission dynamics of the disease in the human or animal populations.

Therefore, to optimise the benefits of immunization programmes, it is important to understand the consequences of extensive vaccinations on the pathogen biology, on the microbial ecosystem, and on the human populations affected by the infection. The results contribute to the definition of optimized strategies of disease prevention.

Some of our projects are described below under the ‘projects’ header. Our unit also hosts the National Reference Centre for Whooping cough and other Bordetelloses and the National reference Centre for Corynebacteriae of the diphtheriae complex.

Some of our projects:

Links to related resources:

Whooping Cough






Head of the Unit : +33(0) 1 45 68 83 34
Deputy Head, NRC Bordetelloses: +33(0) 1 45 68 32 92
Deputy Head, NRC Coryne : +33(0) 1 45 68 94 40
Secretariat : +33(0)1 45 68 80 05

25-28 Rue du Docteur Roux
75015, Paris