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About

Elucidating the molecular basis of cell polarity and mechanisms of intracellular trafficking are fundamental goals in cell biology, not only for the understanding of basic cell function but also because alteration of these processes underlies many diseases. The work in our lab is focused on the study of the molecular mechanisms regulating protein sorting and intracellular trafficking in polarized epithelial cells and neuronal cells, and on the mechanisms of protein(s) and organelle(s) exchanges between cells, with the aim of understanding how these pathways contribute to/are altered in diseases like cancer and neurodegenerative disorders.

To unravel these questions we have applied different approaches including molecular biology, protein/lipid biochemistry, biophysics, mathematical modeling, quantitative high resolution and live imaging in four projects listed below:

Project 1.: Mechanisms of GPI-anchored protein apical sorting and plasma membrane organization in polarized epithelial cells.

Project 2.: Prion-like proteins spreading in neurodegenerative diseases (NDs): role of Tunneling Nanotubes (TNTs).

Project 3.: Role of TNTs in tumor networking, heterogeneity, and resistance to therapy.

Project 4.: Unraveling the structure/function of TNTs in vitro and in vivo.

Members

Former Members

2000
2000
Name
Position
2015
2019
Elise Delage
Post-doc
2015
2019
Saida Abounit
PhD Student
2015
2019
Nathalie Barilone
Technician
2015
2019
Guiliana Victoria
Post-doc
2015
2019
Esthel Penard
Technician
2015
2019
Seng Zhu
PhD Student
2015
2019
Yuan-Ju Wu
PhD Student
2015
2019
Jessica Vargas
Post-doc
2015
2019
Frida Loria Salinas
Post-doc
2015
2019
Clara Grudina
Post-doc
2017
2020
Shaarvari Bhat
PhD Student
2018
2020
Giulia Pinto
PhD Student
2016
2021
Aysegul Dilsizoglu-Senol
Post-doc
2016
2021
Diego Cordero Cervantes
PhD Student/Post-doc
2017
2021
Dandan Liu
PhD Student
2018
2021
Nina Ljubojevic
PhD Student/Post-doc
2018
2022
Maura Samarani
Post-doc
2019
2022
Roberto Notario Manzano
PhD Student
2021
2022
Harshavardhan Khare
Post-doc
2022
2023
Kinga Grabowska
Post-doc
2018
2023
Michael Henderson
Post-doc
2023
2023
Arnon Henn
Visiting Researcher
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Projects

Transversal Project

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Contact

Address: Institut Pasteur 25-28 Rue du Docteur Roux 75015, Paris France https://webcampus.pasteur.fr/GstPlans/DisplayBuildingAction.do?building=02