Macrophages et lymphocytes de souris. Image colorisée.

Teams
Members
Projects
Events
Calls
Jobs
publications
Software
Tools
Network
Equipment

Laboratory

Lymphopoiesis

Head

Ana Cumano

Inserm Paris 7 U1223

Department of Immunology

VIEW ALLClose

About

The Lymphopoiesis Unit, attached to the Immunology Department of the Institut Pasteur, was created in January 2011 and is the follow up of the Unit for Lymphocyte Development created in 1998. It joins the Inserm unit U1223 (previously U668) “Physiopathologie du Système Immunitaire” directed by James Di Santo. Since 2014, the Lymphopoiesis unit is under contract with Université Paris Diderot.

Groups

Group

Macrophages et lymphocytes de souris. Image colorisée.

Paulo Vieira

Group: Development of the Humoral Immune System

Group

Rachel Golub

Group: Rachel Golub

Members

Head

Odile Burlen-Defranoux

Research Engineer

Marie-Christine Vougny

Administrative Staff

Delphine Guy-Grand

Elena-Gaia Banchi

Undergraduate Student

Antonio Bandeira Ferreira

Ana Catarina Cardoso da Silva

PhD Student

Lucia Orsini

Post-doc

Former Members

Damien Garrido

Jerome Van Wassenhove

Jean-Baptiste Beneteau

Program Projects

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur ProjectWhile the immune system […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive ConsortiumMajor advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The medical […]

Projects

Genesis of the peripheral regulatory system.

A fundamental concept on the development of the natural regulatory cells is that the thymus only exports regulatory T cells after the third day post-birth, implying a differential developmental program controlling the generation of […]

Innate lymphoid cell differentiation

We found that RoRgt expressing innate lymphoid cells (ILC) develop in the fetal liver but not in the bone marrow (BM). However, BM progenitors give rise to RoRgt+ILC in the peripheral lymphoid organs and […]

The role of a gradient of the chemokine CXCL12 in hematopoietic development and in a normal immune response. (Collaboration with F. Arenzana-Seisdedos, granted ANR funding)

Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted cells. The laboratory of […]

T cell development

We recently found (Ramond et al 2014, Nat Immunol) that the mouse thymus is colonized by successive waves of progenitors that differ in their developmental stage and function. Our observations show that the T […]

Deregulation of hematopoiesis by Interleukin-10 over-expression (Joint project with the University of Minho, Portugal, granted ANR international funding)

Cytokines are soluble molecules that regulate a large array of developmental processes. In the hematopoietic system, cytokines mediate the production of mature blood cells from specific lineages, by directly acting on hematopoietic progenitors. Cytokines […]