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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.

About

The Lymphopoiesis Unit, attached to the Immunology Department of the Institut Pasteur, was created in January 2011 and is the follow up of the Unit for Lymphocyte Development created in 1998. It joins the Inserm unit U1223 (previously U668) “Physiopathologie du Système Immunitaire” directed by James Di Santo. Since 2014, the Lymphopoiesis unit is under contract with Université Paris Diderot.

figure_lymphopoiese.jpg

 

 

Members

Ana Cumano
Head of Structure
Head
Pablo Pereira Esteva
Permanent Researcher
Paulo Vieira
Group Leader
Rachel Golub
Group Leader
Thibaut Perchet
PhD Student
Odile Burlen-Defranoux
Research Engineer
Marie-Christine Vougny
Administrative Staff
Delphine Guy-Grand
Ramy Elsaid
PhD Student
Junjie Yang
PhD Student
Antonio Bandeira Ferreira
Permanent Researcher
Maxime Petit
PhD Student
Ana Catarina Cardoso da Silva
PhD Student
Francisca Soares Da Silva
PhD Student
Françoise Guinet
Permanent Researcher
Sylvain Meunier
Non-permanent Researcher

Projects

project
Ongoing
6 Members

The role of lncRNA H19 in Thymopoiesis

Ana Cumano (PI)

“The thymus is a specialized organ that provides a unique environment for T cell development and differentiation. The study the thymus-settling progenitors (TSPs) and how they differentiate is important for the characterization of the […]
project
Ongoing
2 Members

Genesis of the peripheral regulatory system.

Antonio Bandeira Ferreira (PI)

A fundamental concept on the development of the natural regulatory cells is that the thymus only exports regulatory T cells after the third day post-birth, implying a differential developmental program controlling the generation of […]
project
Ongoing
6 Members

Innate lymphoid cell differentiation

Rachel Golub (PI)

We found that RoRgt expressing innate lymphoid cells (ILC) develop in the fetal liver but not in the bone marrow (BM). However, BM progenitors give rise to RoRgt+ILC in the peripheral lymphoid organs and […]
project
Ongoing
2 Members

The role of a gradient of the chemokine CXCL12 in hematopoietic development and in a normal immune response. (Collaboration with F. Arenzana-Seisdedos, granted ANR funding)

Paulo Vieira (PI)

Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted cells. The laboratory of […]
project
Ongoing
6 Members

T cell development

Ana Cumano (PI)

We recently found (Ramond et al 2014, Nat Immunol) that the mouse thymus is colonized by successive waves of progenitors that differ in their developmental stage and function. Our observations show that the T […]
project
Ongoing
3 Members

Deregulation of hematopoiesis by Interleukin-10 over-expression (Joint project with the University of Minho, Portugal, granted ANR international funding)

Paulo Vieira (PI)

Cytokines are soluble molecules that regulate a large array of developmental processes. In the hematopoietic system, cytokines mediate the production of mature blood cells from specific lineages, by directly acting on hematopoietic progenitors. Cytokines […]

Transversal Project

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

LabEx Revive – Regenerative biology & medicine

  Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. […]

Fundings

Partners

Publications