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© Deriano Lab / Institut Pasteur
Chromosomes métaphasiques d’une cellule lymphoïde cancéreuse présentant une amplification des gènes Igh et c-myc

About

CANCER FROM WITHIN: immune cells reveal insights into mechanisms of DNA recombination and tumorigenesis. Lymphocytes are unique cell types of our adaptive immune system that require multiple rounds of cell divisions during their development and, most strikingly, multiple rounds of gene rearrangements during the formation of their antigen receptors. Our research major goal is to understand the mechanisms by which a lymphoid cell maintains the integrity of its DNA and prevents genomic instability and transformation. We study the DNA recombination processes – V(D)J recombination and class switch recombination – that are part of B- and T-cell development and the general DNA double-strand break response and repair mechanisms and pathways that lead to genetic instability and cancer.

Former Members

2000
2000
Name
Position
2013
2014
Tiama El Chaar
Postdoctoral Fellow
2013
2014
Christophe Clouin
Postdoctoral Fellow
2013
2014
Nicole Clarke
Visiting PhD Student (Stanford University)
2015
2019
Valentine Murigneux
Research Engineer - Bioinformatics - Computational biology
2014
2019
Joy Bianchi
Master and PhD Student
2015
2018
helene Lenden-Hasse
Research Engineer
2015
2020
Wei Yu
Postdoctoral Fellow
2017
2020
Wenming Wei
PhD Student
2020
2021
Eva Guerin
Master student (EPHE)
2021
2021
Tristan Espie--Caullet
Master student (AgroParisTech)

Projects

Project
Ongoing
2 Members

Study of DNA double-strand break repair regulation in B cells – implication for cancer therapy

Ludovic Deriano (PI)

Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]
Project
Ongoing
2 Members

Mechanisms and consequences of chromosomal translocations

Ludovic Deriano (PI)

Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]
Project
Completed
10 Members

Think tank: Cancer

Ludovic Deriano (PI)

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Project
Completed
6 Members

ERC-2012-StG LymphoOncoGenomics

Ludovic Deriano (PI)

Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
Project
Ongoing
4 Members

FROM PHYSIOLOGICAL DNA REARRANGEMENTS TO LYMPHOID CANCERS

Ludovic Deriano (PI)

  B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]
Project
Ongoing
5 Members

MECHANISMS OF DNA RECOMBINATION

Ludovic Deriano (PI)

  DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]

Transversal Project

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

Fundings

Publications

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Pictures & Media

 

DERIANO lab June 2021 – from left to right : Timea Marton, Ludovic Deriano, Danièle Sinnaya, Chloé Lescale, Estelle Vincendeau, Billie Libri, Tristan Estie–Caullet, Eva Guerin, François Dossin, (Marie Bedora-Faure, not on the picture).

238A6135

DERIANO lab July 2016 – from left to right : Jean Eudes Fahrner, Marie Bedora-Faure, Chloé Lescale, Valentine Murigneux, Wei Yu, Ludovic Deriano, Joy Bianchi, Léa Bacoccina, Hélène Lenden-Hasse, (Danièle Sinnaya – not on the picture).

Contact

Phone: +33 (0)1 44 38 93 55 Email: ludovic.deriano@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France