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About

The laboratory of Immunobiology of Dendritic Cells applies a bedside-to-bench approach to scientific discovery that ensures our team stays rooted in medically relevant questions, while striving to make new fundamental discoveries about immunity to disease.

Our laboratory is a mixed INSERM / Pasteur Unit. Our original founding scientific objective was to characterize immune responses initiated by dying cells. The commitment to this field of study stems from our discovery that dead cells serve as a source of antigen for dendritic cell cross-presentation and cross-priming. As the group has evolved, we have tackled this from multiple perspectives with the findings leading to new projects in unexpected directions. Our principle scientific aims are:

  1. Defining how variable cell death programs influence inflammation and immunity
  2. Understanding how immunity is initiated from the bladder mucosa in the context of infection and cancer immunotherapy
  3. Exploring the mechanisms that limit inflammation and control the trafficking of effector immune cells

In addition to these scientific research goals, we are transfering our insights into biomarkers for treatment response and drug targets for improving treatment outcome, back into the clinic completing the circle “bench-to-bedside”. For these clinical studies, we have been focusing on viral hepatitis and cancer.

Our laboratory has played a leading role in the establishment of the Milieu Intérieur Project. We contributed our expertise to the development and use of whole blood syringe-based assay systems (TruCulture) that can be used to reproducibly assess induced innate or adaptive immune responses. Early results from the Consortium’s work have provided an initial assessment of healthy donor reference values for microbe-induced cytokines and chemokines. Our laboratory is now focusing on the deconvolution of the healthy immune response, and applying these approaches for a better understanding of perturbed immune responses in viral hepatitis and tuberculosis.

 

Members

Former Members

2000
2000
Name
Position
2015
2020
Charlotte Auriau
Technician
2015
2020
Rosa Maria Barreira Da Silva
Post-doc
2015
2020
Claire Biot
PhD Student
2015
2020
Isabelle Bouvier
PhD Student
2015
2020
Matthew Buckwalter
2015
2020
Jérémie Decalf
Post-doc
2015
2020
Gabriela Mora
PhD Student
2015
2020
Pierre-Emmanuel Joubert
Permanent Researcher
2015
2020
Clementine Schilte
Project Manager
2015
2020
Philippe Sultanik
2015
2020
Martin Uhl
Permanent Researcher
2015
2020
Lisa Walter
Post-doc
2015
2020
Scott William Werneke
Post-doc
2015
2020
Biljana Zafirova
Post-doc
2015
2020
Vincent Rouilly
Research Engineer
2015
2020
Armanda Casrouge
Research Engineer
2015
2020
Stéphanie Thomas
Project Manager
2015
2020
Brieuc Perot
Post-doc
2015
2020
Matthew Albert
Permanent Researcher
2015
2020
Alejandra Urrutia
Research Engineer
2015
2020
Cécile Alanio
Post-doc
2015
2020
Conan O’Brien
Undergraduate Student
2015
2020
Clemence Hollande
PhD Student
2015
2020
Emma Vayssieres
Undergraduate Student
2015
2020
Eduardo ANTEQUERA
Undergraduate Student
2015
2020
Nader Yatim
Post-doc
2015
2020
Tracy Canton
Technician
2015
2020
Jérémy Boussier
PhD Student
2015
2020
Negar Seyed
Assistant Professor
2015
2020
Camila Consiglio
PhD Student
2015
2020
Dalil Aouni
Undergraduate Student
2015
2020
Naina GOEL
Undergraduate Student
2015
2020
Aurélie Bisiaux
Research Engineer
2015
2020
Hsien Neng Kao
PhD Student
2015
2020
Federico Lupo
Undergraduate Student
2015
2020
Jamie Sugrue
PhD Student
2015
2020
Eva Pico
PhD Student
2015
2020
Julien Desclés
Project Manager
2015
2020
Alba Llibre Serradell
Post-doc
2020
2020
Jakob Von Stemann

Projects

Transversal Project

Fundings

Publications

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Contact

Phone: 01 45 68 89 02 Email: matthew.albert@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France