How the dynamics of signaling complexes at the immunological synapse controls T cell activation
Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli
Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]
2017Cell Biology of T Cell Receptor Expression and Regulation, Annu. Rev. Immunol. 2017 Dec;.
2017Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function, PLoS ONE 2017;12(1):e0170396.
2016Comparative Anatomy of Phagocytic and Immunological Synapses, Front Immunol 2016;7:18.
2011Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation, J. Cell Biol. 2011 Nov;195(5):839-53.
2008Tailoring T-cell receptor signals by proximal negative feedback mechanisms, Nat. Rev. Immunol. 2008 Sep;8(9):699-712.
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