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Rodent and human malaria models to investigate host-parasite interactions central for malaria pathogenesis
Salah Mecheri (PI)
During the past few years, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the […]
2017Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite, Sci Rep 2017 Aug;7(1):9129.
2017The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria, Sci Rep 2017 Feb;7:42243.
2016Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites, Sci Rep 2016 Feb;6:21802.
2015Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort, Allergy Asthma Clin Immunol 2015;11(1):24.
2015Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity, Infect. Immun. 2015 Jul;83(7):2771-84.
2014Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease, Cell. Microbiol. 2015 Apr;17(4):542-58.
2013Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis, PLoS ONE 2013;8(7):e69183.
2013Asthma and atopic dermatitis are associated with increased risk of clinical Plasmodium falciparum malaria, BMJ Open 2013;3(7).
2012Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum, Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109(41):16708-13.
2012Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging, FASEB J. 2012 Oct;26(10):3969-79.
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