Cellular senescence stably arrests cell proliferation in response to numerous stress stimuli, many of which can initiate or promote aging and age-related diseases. As such, research on therapeutic strategies exploting senescence targeting for healthspan improvement has gained immense momentum. Within this context, our group investigates the impact of dynamic epigenome and transcriptome changes in senescence to unravel “achilles heels” of senescent cells . We anticipate that our research will lay tangible groundwork to exploit senescence targeting as a means to improve or extend healthy lifespan.
Members
Former Members
2000
2000
Name
Position
2015
2019
Ricardo Iván Martínez-Zamudio
Post-doc
2015
2019
Pierre-François Roux
Post-doc
2015
2019
Group: Oliver Bischof
Projects
Transversal Project
Publications
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2020AP-1 imprints a reversible transcriptional programme of senescent cells., 2020 07; 22(7): 842-855.
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2020Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells., 2020 ; 2020(): 7865484.
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2019Cellular Senescence: Defining a Path Forward., 2019 10; 179(4): 813-827.
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2018Author Correction: Necroptosis microenvironment directs lineage commitment in liver cancer., Nature 2018 12; 564(7735): E9.
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2018Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence, Cell. Physiol. Biochem. 2018;51(3):1103-1118.
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2018Response to Letter to the Editor: Epigenetic Aging in Osteoporosis, J. Bone Miner. Res. 2018 Oct;33(10):1904-1905.
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2018Necroptosis microenvironment directs lineage commitment in liver cancer, Nature 2018 10;562(7725):69-75.
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2017Senescence is a Spi1/PU.1-induced anti-proliferative mechanism in primary hematopoietic cells, Haematologica 2017 Sep;.
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2017SnapShot: Cellular Senescence in Pathophysiology, Cell 2017 Aug;170(5):1044-1044.e1.
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2017SnapShot: Cellular Senescence Pathways, Cell 2017 Aug;170(4):816-816.e1.
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Contact
Address 25-28 Rue du Docteur Roux 75015, Paris France