Cellular senescence stably arrests cell proliferation in response to numerous stress stimuli, many of which can initiate or promote aging and age-related diseases. As such, research on therapeutic strategies exploting senescence targeting for healthspan improvement has gained immense momentum. Within this context, our group investigates the impact of dynamic epigenome and transcriptome changes in senescence to unravel “achilles heels” of senescent cells . We anticipate that our research will lay tangible groundwork to exploit senescence targeting as a means to improve or extend healthy lifespan.
Molecular and Cellular Biology of Cellular Senescence and Age-Related Pathologies
Aging is multifactorial, resulting in a progressive loss of regenerative capacity and tissue function while simultaneously favoring disease development. There is strong evidence that one or more basic aging process is a pivotal driver […]
2017Senescence is a Spi1/PU.1-induced anti-proliferative mechanism in primary hematopoietic cells, Haematologica 2017 Sep;.
2017SnapShot: Cellular Senescence in Pathophysiology, Cell 2017 Aug;170(5):1044-1044.e1.
2017SnapShot: Cellular Senescence Pathways, Cell 2017 Aug;170(4):816-816.e1.
2017Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells, Sci Rep 2017 Jul;7(1):5132.
2017Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression, Nat Commun 2017 May;8:14995.
2017Cytokine-induced senescence for cancer surveillance, Cancer Metastasis Rev. 2017 Apr;.
2016Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence, Proc. Natl. Acad. Sci. U.S.A. 2016 Aug;113(34):E5024-33.
2016USP1 Regulates Cellular Senescence by Controlling Genomic Integrity, Cell Rep 2016 May;15(7):1401-11.
2015MicroRNAs and lncRNAs in senescence: A re-view, IUBMB Life 2015 Apr;67(4):255-67.
2014Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit, Nat Commun 2014 Nov;5:5323.
+View full list of publications
Pictures & Media
25-28 Rue du Docteur Roux