Developement of inhibitors targeting the protein synthesis machinery of Trypanosomatids
Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from adherence, motility, […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
20171H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system., Biomol NMR Assign. 2017 Mar 3. doi: 10.1007/s12104-017-9738-7. .
2017Structure of the calcium-dependent type 2 secretion pseudopilus, Nat Microbiol. 2017 Oct 9. doi: 10.1038/s41564-017-0041-2.
2016Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach., Biochem J. 2016 May 13. pii: BCJ20160131.
2015A tribute to Cécile Wandersman, Res. Microbiol. 2015 Jun;166(5):393-8.
2015NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi, J. Struct. Biol. 2015 Apr;190(1):11-20.
2014(1)H, (15)N and (13)C resonance assignments and secondary structure prediction of Q4D059, a conserved and kinetoplastid-specific hypothetical protein from Trypanosoma cruzi, Biomol NMR Assign 2015 Apr;9(1):161-3.
2014Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR, PLoS ONE 2014;9(4):e89502.
2013Solution NMR analysis of the interaction between the actinoporin sticholysin I and DHPC micelles–correlation with backbone dynamics, Proteins 2014 Jun;82(6):1022-34.
2013The structure of HasB reveals a new class of TonB protein fold, PLoS ONE 2013;8(3):e58964.
2012¹H, ¹⁵N and ¹³C resonance assignments of PpdD, a type IV pilin from enterohemorrhagic Escherichia coli, Biomol NMR Assign 2014 Apr;8(1):43-6.
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