One of the most prominent features of archaea is the extraordinary diversity of their DNA viruses. Many archaeal viruses differ substantially in morphology from bacterial and eukaryotic viruses and represent unique virus families. For instance, viruses with bottle-shaped, lemon-shaped, coil-shaped or droplet-shaped virions are thus far exclusive to the Archaea. The distinct nature of archaeal viruses also extends to the gene composition and architectures of their genomes, and the properties of the proteins that they encode. Environmental research has revealed prominent roles of archaeal viruses in influencing microbial communities in ocean ecosystems, and recent metagenomic studies have uncovered new groups of archaeal viruses that infect extremophiles and mesophiles in diverse habitats. We are exploring the extent of archaeal virus diversity in different habitats and different aspects of their biology, including virion structure and assembly, molecular mechanisms of their entry and egress as well as other aspects of virus-host interaction.
ANR-ENVIRA: Membrane remodeling by enveloped viruses of Archaea
Mart Krupovic (PI)
Membrane remodeling is a fundamental and necessary process underlying proper functioning of cellular organisms in all three domains of life. Much of our knowledge on the mechanisms of membrane fusion and scission, two of […]
2019Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids, Nat Commun 2019 Jul;10(1):3425.
2019Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth’s biomes, Nat Microbiol 2019 Jul;.
2019Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea, Proc. Natl. Acad. Sci. U.S.A. 2019 Jul;.
2019Origin of programmed cell death from antiviral defense?, Proc. Natl. Acad. Sci. U.S.A. 2019 Jul;.
2019Origin of viruses: primordial replicators recruiting capsids from hosts, Nat. Rev. Microbiol. 2019 May;17(7):449-458.
2019Sequence motifs recognized by the casposon integrase of Aciduliprofundum boonei, Nucleic Acids Res. 2019 May;.
2019An extensively glycosylated archaeal pilus survives extreme conditions, Nat Microbiol 2019 May;.
2019Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks, Nat. Biotechnol. 2019 May;.
2019Novel haloarchaeal viruses from Lake Retba infecting Haloferax and Halorubrum species, Environ. Microbiol. 2019 Mar;.
2019Integrated mobile genetic elements in Thaumarchaeota, Environ. Microbiol. 2019 Feb;.
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