Type I IFNs (IFNα/β) are rapidly produced in response to pathogens and cellular aggressions. As a result, these cytokines promote the early development of innate and adaptive immune responses. However, their immunomodulatory effect is complex as they can drive pro- and anti-inflammatory responses. The anti-inflammatory function of IFN-I is beneficial in the treatment of the relapsing-remitting form of multiple sclerosis, a chronic autoimmune neurodegenerative disease. Conversely, a deleterious effect of IFN-I has been reported in different types of inflammatory diseases and upon chronic antigen exposure. Our main interest is to decipher signaling and molecular mechanisms underlying the shaping effect of IFN-I on the development of anti- and pro-inflammatory CD4 T cell subsets. We are also interested in pathophysiological mechanisms operating in immune disorders.
Cellular and molecular immunoprofiling of multiple sclerosis patients
This project aims at providing new knowledge on the immunomodulatory effect of IFN-I in multiple sclerosis patients by using state-of-the-art technologies. An important challenge is the identification of cellular and molecular biomarkers of IFN […]
Role of IFN-I in the development of IL-10-producing CD4 T cells
We have shown that IFN-I promotes development of human type 1 regulatory-like cells (Tr1) that produce the anti-inflammatory cytokine IL-10, and have studied the integration of T cell receptor (TCR) signal strength and CD28 […]
2013Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells, Eur. J. Immunol. 2013 Oct;43(10):2730-40.
2013Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent, J. Immunol. 2013 Mar;190(5):2335-44.
2010T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells, PLoS ONE 2010;5(11):e15114.
2007A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76, J. Exp. Med. 2007 Mar;204(3):681-91.
2006T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2, J. Exp. Med. 2006 Oct;203(11):2509-18.
2005Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function, Proc. Natl. Acad. Sci. U.S.A. 2005 Sep;102(36):12855-60.
2003CD28-mediated co-stimulation: a quantitative support for TCR signalling, Nat. Rev. Immunol. 2003 Dec;3(12):939-51.
2003Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor, Immunol. Rev. 2003 Apr;192:21-31.
2002CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling, Nat. Immunol. 2003 Feb;4(2):189-97.
2002CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?, Sci. STKE 2002 Aug;2002(144):pe35.
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