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About

Type I IFNs (IFNα/β) are rapidly produced in response to pathogens and cellular aggressions. As a result, these cytokines promote the early development of innate and adaptive immune responses. However, their immunomodulatory effect is complex as they can drive pro- and anti-inflammatory responses. The anti-inflammatory function of IFN-I is beneficial in the treatment of the relapsing-remitting form of multiple sclerosis, a chronic autoimmune neurodegenerative disease. Conversely, a deleterious effect of IFN-I has been reported in different types of inflammatory diseases and upon chronic antigen exposure. Our main interest is to decipher signaling and molecular mechanisms underlying the shaping effect of IFN-I on the development of anti- and pro-inflammatory CD4 T cell subsets. We are also interested in pathophysiological mechanisms operating in immune disorders.

Former Members

2000
2000
Name
Position
2015
2019
Yasmine Bourdache
2015
2019
Umeshree Govender
PhD Student
2015
2019
Béatrice Corre
Technician
2015
2019
Aïda Meghraoui
Post-doc

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Contact

Phone: 01 45 68 86 38
Email: frederique.michel@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France