Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets
Scientific Background Differentiation of naïve CD4+ T lymphocytes into functionally distinct T helper cell subsets is essential for efficient immune responses against different types of pathogens. Effector T cell lineages selectively produce specific sets […]
2014RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer’s disease, Neurobiol. Dis. 2014 Sep;69:169-79.
2014Dynamic regulation of the COP9 signalosome in response to DNA damage, Mol. Cell. Biol. 2014 Mar;34(6):1066-76.
2014RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain, J. Alzheimers Dis. 2014;39(4):727-40.
2013COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels, J. Biol. Chem. 2013 Sep;288(37):26668-77.
2013Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease, Blood 2013 Sep;122(10):1802-12.
2013RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice, PLoS ONE 2013;8(6):e66908.
2013RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes, Cell Death Dis 2013;4:e667.
2013Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis, Arthritis Rheum. 2013 Jun;65(6):1510-21.
2012Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain, FASEB J. 2012 May;26(5):2072-83.
2010The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation, J. Biol. Chem. 2010 Jun;285(23):17390-7.
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