Structural studies of type II topoisomerases
Our main research projects focus on structural and functional studies of M. tuberculosis DNA gyrase and aim to understand the structural dynamics of DNA recognition by DNA gyrase and the quinolone resistance mechanisms […]
Crl: a “binding and deliver” SigmaS chaperone
Regulation of many key biological processes in bacteria involves the interplay between Sigma factors and anti-Sigma factors that typically attenuate Sigma factor function by restricting its access to RNA polymerase (RNAP). In contrast, our […]
Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]
ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases
Organic synthesis, still the limiting factor of Medicinal Chemistry? This ongoing project is based on our reviews (1-3) on the inhibitors of the ATPase functions of human heat shock protein 90 (HSP90) or bacterial […]
2019Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity, Structure 2019 04;27(4):579-589.e5.
2016Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis, Tuberculosis (Edinb) 2016 09;100:15-24.
2016Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis, J. Antimicrob. Chemother. 2016 May;.
2016Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors, Can. J. Chem. 2016, 94 , 240-250.
2014Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase, Biochem. J. 2014 Oct;463(2):215-24.
2014The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosis, Microbiol Spectr 2014 Aug;2(4):MGM2-0009-2013.
2014DNA topoisomerase VIII: a novel subfamily of type IIB topoisomerases encoded by free or integrated plasmids in Archaea and Bacteria, Nucleic Acids Res. 2014 Jul;42(13):8578-91.
2014Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism, Chem. Rev. 2014 Feb;114(4):2313-42.
2013Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion, Biochem. J. 2013 Dec;456(2):263-73.
2013Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes, Biochem. J. 2013 Nov;455(3):285-94.
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