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© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

project
Ongoing
4 Members

Structural studies of type II topoisomerases

Claudine Mayer (PI)

  Our main research projects focus on structural and functional studies of M. tuberculosis DNA gyrase and aim to understand the structural dynamics of DNA recognition by DNA gyrase and the quinolone resistance mechanisms […]
project
Ongoing
14 Members

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

Claudine Mayer (PI)

Organic synthesis, still the limiting factor of Medicinal Chemistry?   This ongoing project is based on our reviews (1-3) on the inhibitors of the ATPase functions of human heat shock protein 90 (HSP90) or […]
project
Completed
3 Members

Crl: a “binding and deliver” SigmaS chaperone

Françoise Norel-Bozouklian (PI)

Regulation of many key biological processes in bacteria involves the interplay between Sigma factors and anti-Sigma factors that typically attenuate Sigma factor function by restricting its access to RNA polymerase (RNAP). In contrast, our […]
project
Completed
5 Members

MM4TB

Pedro Alzari (PI)

Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]

Fundings

Publications

Contact

Phone: 10 45 68 83 87
Email: mayer@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France