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  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
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  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Group

Group: Molecular Biology of Hepatitis B virus

Department of Virology

Scientific Fields
Diseases
Organisms
Applications
Technique

About

Despite effective prevention against hepatitis B virus (HBV )infection, 300 million people worldwide are chronic HBV carriers, of whom 25% will die of liver cirrhosis or hepatocellular carcinoma (HCC). Although antiviral treatments of chronic HBV carriers, including pegylated interferon-alpha and inhibitors of the viral polymerase, control efficiently virus replication and improve liver functions, they cannot lead to a complete viral clearance. This failure is due to the inability of the treatment to eliminate the viral DNA present in the nucleus of infected cells as a covalently closed circular DNA (cccDNA). cccDNA serves as a template for the transcription of all viral RNAs and thus constitutes a viral reservoir responsible for viral rebound at the end of the treatment. Our group investigates mechanisms regulating HBV cccDNA transcription and persistence.

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Contact

Phone: 33 1 45 68 87 76
Email:christine.neuveut@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France