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About

We are interested in RNA metabolism and our results cover a large array of different cellular processes involving RNA, like the identification of novel transcripts, the assembly and the transport of ribonucleoprotein particles or the mechanisms of mRNA degradation in the cytoplasm. We use the yeast Saccharomyces cerevisiae as a model organism and try to develop novel genomic-scale tools for this unicellular eukaryote.

 

Former Members

Former members (approximate period) Alice Lebreton (2004-2008), Emilie Demoinet (2004-2008), Yanhua Yao (2007-2011), Quentin Defenouillere (2010-2014), Luciana Lazar Stefanita (2011-2012), Thomas Kergrohen (2014-2015), Simon Malesys (2014-2016) Christophe Malabat (2008-2014), Marine Dehecq (2014-2018), Elodie Zhang (2015-2018), Antonia Doyen (2008-2016), Alicia Chery – Faleme (2015-2018), Estelle Dacheux (2018-2020), Varun Khanna (2015-2019)

Courses

00:01
13
Feb 2017
Course

Multiple Roles of RNAs

I have been appointed in 2013 Co-director together with Pr Yannick Andéol of the Multiple Role of RNAs Pasteur course. This two-week theorical and practical course presents RNA related technics  (RNA seq, Northern blot […]
Genetics of Macromolecular Interactions
Institut Pasteur
Genomes and Genetics
Hervé Waxin
2017-02-13 00:01:10 2017-02-25 18:00:00 Europe/Paris Multiple Roles of RNAs I have been appointed in 2013 Co-director together with Pr Yannick Andéol of the Multiple Role of RNAs Pasteur course. This two-week theorical and practical course presents RNA related technics  (RNA seq, Northern blot […] 28 Rue du Docteur Roux, Paris, France

Projects

Project
Ongoing
5 Members

Cytoplasmic mRNA degradation pathways

Micheline Fromont-Racine (PI)

Cellular mRNAs are subjected to a balance between synthesis and degradation, which determines the shape of the transcriptome and greatly participates to protein homeostasis. In addition to the general degradation pathways, which ensure the […]
Project
Ongoing
7 Members

Translation and Ribosome rescue

Micheline Fromont-Racine (PI)

Translation involves four main steps: initiation, elongation, termination and recycling. Each step is highly controlled and can be modulated depending on the mRNA characteristics. The first step begins with the binding of eIF3 to […]
Project
Completed
9 Members

A personal database system for large scale quantitative results exploration (Cassandre, PTR 463)

Christophe Malabat (PI)

Cassandre is a project of personal database system, integrating a “user-friendly” interface to manage and explore multiple sets of large-scale experimental results in biology. Large-scale experiments that generate quantitative data, such as changes in […]
Project
Ongoing
4 Members

Quality Control at the Ribosome

Micheline Fromont-Racine (PI)

Gene expression is controlled and regulated by nuclear and cytoplasmic surveillance mechanisms in order to preserve the integrity of genetic information. Some of the mechanisms occur in the nucleus during transcription and maturation of […]
Project
Ongoing
5 Members

Diversity and stability of eukaryotic transcripts

Alain Jacquier (PI)

We focus on RNA quality control mechanisms and their consequences for the cells. Our previous studies revealed, for example, unexpected properties of the transcription process, such as its high pervasiveness and the intrinsic bi-directionality […]
Project
Ongoing
7 Members

Non-sense mediated mRNA decay mechanisms

Cosmin Saveanu (PI)

Non-sense mediated mRNA decay (NMD) is a fundamental and conserved mechanism with a major role in shaping the levels of individual RNAs in a eukaryotic cell by efficiently removing RNAs in which a stop […]
Project
Ongoing
6 Members

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

Cosmin Saveanu (PI)

To explore the effects of combining mutations and thus, be able to better understand complex functional interactions in a cell, we developed a novel genetic screening method that combines the exhaustivity of the yeast […]

Publications

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Contact

Address 25-28 Rue du Docteur Roux 75015, Paris France