Our aim is to understand how the structural organization of the genome contributes and influences genomic functions and notably gene expression. We are particularly interested into the role of the 3D architecture of the genome in the regulation of developmental genes by distant cis-acting elements. We use and develop novel in vivo genomic and chromatin engineering strategies as well as functional genomics approaches to investigate and uncover the molecular determinants that translate a linear sequence into specific 3D domains and dispersed regulatory information into specific and robust gene expression programs. We are as well studying how changes in these mechanisms and genome structure contribute to animal evolution and human pathologies.
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Mini Symposium and Workshop – Single cell @ Pasteur
Building: Duclaux – Room: Duclaux – Address: 28 Rue du Dr Roux, 75015 Paris, France
2017-11-13 13:00:00 2017-11-13 18:00:00 Europe/Paris Mini Symposium and Workshop – Single cell @ Pasteur The aims of this Mini Symposium are to discuss the recent developments in single cell genetic and genomic technologies and present the new technological pipelines available at Pasteur to conduct such experiments. Welcome and […] 28 Rue du Dr Roux, 75015 Paris, France
2018A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies, Nature 2018 Jan;553(7689):515-520.
2017Two independent modes of chromatin organization revealed by cohesin removal, Nature 2017 Nov;551(7678):51-56.
2016The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances, Dev. Cell 2016 39(5) 529-543.
2016Formation of new chromatin domains determines pathogenicity of genomic duplications, Nature. 2016;538: 265–269..
2016Gene regulation at a distance: from remote enhancers to 3D regulatory ensembles, Semin. Cell Dev. Biol. 2016 Jun;.
2016Cis-regulatory architecture of a brain signaling center predates the origin of chordates, Nat. Genet. 2016 May;48(5):575-80.
2015Gene regulation during development in the light of topologically associating domains, Wiley Interdiscip Rev Dev Biol 2016 Mar-Apr;5(2):169-85.
2015Model mice for 15q11-13 duplication syndrome exhibit late-onset obesity and altered lipid metabolism, Hum. Mol. Genet. 2015 Aug;24(16):4559-72.
2015Hoxa2 selectively enhances Meis binding to change a branchial arch ground state, Dev. Cell 2015 Feb;32(3):265-77.
2015A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes, PLoS Genet. 2015 Jan;11(1):e1004897.
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