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About

The huge amount of molecular data available nowadays can help addressing new and essential questions in evolution. However, reconstructing evolution requires models, algorithms, and statistical and computational methods of ever increasing complexity. Developing methods that scale with the “deluge” of data is a real challenge, in terms of algorithmics but also modeling. Out unit aims at developing new methodologies and algorithms that are able to tackle efficiently these challenges, in the field of evolution and molecular phylogeny.

Our second aim is to apply these methods and tools to pathogens, mostly viruses, and especially HIV. The goals are multiple: understand their evolution (e.g. the emergence and transmission of drug resistance mutations), decipher their genome (e.g. to confirm the existence of the 10th gene of HIV), design surveillance tools (e.g. to control outbreaks). Most of the current methods to tackle these questions are based on Bayesian approaches, which are computationally heavy and not able to process the large data sets available nowadays. To overcome these limitations we are working on new maximum-likelihood and approximate bayesian methods (ABC) applicable to very large data sets comprising several dozens of thousands of sequences.

Courses

Behind Evolutionary Trees: Mathematics and Algorithms in Phylogenetics – Montevideo 2019

Evolutionary trees are used in many domains, to reveal the function of genes, study the outbreak of epidemics, and set up inventories of biodiversity and its decline, among other things. Phylogenetic software programs for […]

2019-10-22 09:00:00 2019-10-24 17:00:00 Europe/Paris Behind Evolutionary Trees: Mathematics and Algorithms in Phylogenetics – Montevideo 2019 Evolutionary trees are used in many domains, to reveal the function of genes, study the outbreak of epidemics, and set up inventories of biodiversity and its decline, among other things. Phylogenetic software programs for […] Institut Pasteur de Montevideo, Mataojo, Montevideo Montevideo Department, Uruguay

Mathematical and Computational methods for Phylogenetics and Evolutionary Epidemiology – Havana 2019

Mathematical and Computational concepts and models are essentials in new developments of the evolutionary studies related to outbreaks of infectious diseases pandemics.  Predicting, assessing and controlling potential outbreaks are key aspects of the worldwide […]

2019-10-14 09:00:00 2019-10-18 16:00:00 Europe/Paris Mathematical and Computational methods for Phylogenetics and Evolutionary Epidemiology – Havana 2019 Mathematical and Computational concepts and models are essentials in new developments of the evolutionary studies related to outbreaks of infectious diseases pandemics.  Predicting, assessing and controlling potential outbreaks are key aspects of the worldwide […] Institute of Tropical Medicine “Pedro Kourí” (IPK), Havana, Cuba

Introduction à la Phylogénie Moléculaire : Concepts, méthodes et interprétation

Ce cours a pour objectif de donner les bases théoriques et pratiques, ainsi que les bonnes pratiques nécessaires au démarrage de travaux en phylogénie et épidémiologie moléculaires. Les sessions théoriques donneront les bases du […]

2019-10-07 09:30:00 2019-11-11 17:30:00 Europe/Paris Introduction à la Phylogénie Moléculaire : Concepts, méthodes et interprétation Ce cours a pour objectif de donner les bases théoriques et pratiques, ainsi que les bonnes pratiques nécessaires au démarrage de travaux en phylogénie et épidémiologie moléculaires. Les sessions théoriques donneront les bases du […] 28 Rue du Dr Roux, Paris, France

INTRODUCTION À LA PHYLOGÉNIE MOLÉCULAIRE : CONCEPTS, METHODES ET OUTILS

Nous proposons une formation classique à la phylogénie moléculaire avec des cours théoriques portant sur les trois méthodes de construction d’arbres phylogénétiques : distance, parcimonie et maximum de vraisemblance. Nous expliquerons les concepts généraux […]

2017-12-18 09:30:00 2017-12-22 17:30:00 Europe/Paris INTRODUCTION À LA PHYLOGÉNIE MOLÉCULAIRE : CONCEPTS, METHODES ET OUTILS Nous proposons une formation classique à la phylogénie moléculaire avec des cours théoriques portant sur les trois méthodes de construction d’arbres phylogénétiques : distance, parcimonie et maximum de vraisemblance. Nous expliquerons les concepts généraux […] 25-28 Rue du Dr Roux, 75015 Paris, France

C3BI Course: Introduction to Molecular Phylogenetics – Hong Kong 2018

General Information: This introductory course aims to give the basic theoretical and practical concepts, best practices, and software necessary to start working on molecular phylogenetics and its applications to epidemiology. The course will have […]

2018-10-22 08:00:00 2018-10-27 19:00:00 Europe/Paris C3BI Course: Introduction to Molecular Phylogenetics – Hong Kong 2018 General Information: This introductory course aims to give the basic theoretical and practical concepts, best practices, and software necessary to start working on molecular phylogenetics and its applications to epidemiology. The course will have […] HKU-Pasteur Research Pole HKJC Building for Interdisciplinary Research 5 Sassoon Road, Pokfulam, Hong Kong

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