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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.

About

The research in the Unit of Chemistry and Biocatalysis focuses on the design and synthesis of new chemical entities (mainly nucleos(t)ide analogues and related heterocyclic compounds) targeting enzymes from nucleoside metabolism, and the characterization of unexplored protein targets. The unit also manages the CBC activity (Group H. Munier-Lehmann).

The unit is currently developing modified nucleos(t)ides as substrate mimics to provide insight into enzyme substrate recognition, as well as libraries of functionalized heterocycles useful for the fragment based approach. Novel enzymatic routes (transglycosylation, deamination, phosphorylation) as an alternative to chemical approaches are also considered. Synthesized molecules find applications in the identification of inhibitors of essential bacterial enzymes (TMPK from Mycobacterium tuberculosis, NAD kinases from Gram-positive bacteria), the characterisation of a previously undescribed mammalian nucleotide N– hydrolase involved in cell proliferation (DNPH1). In addition, the new chemical entities implement the in house chemical libraries.

The  Chemistry and Biocatalysis Unit is associated with the CNRS (UMR3523)

Former Members

2000
2000
Name
Position
2015
2020
Pierre Alexandr Kaminski
Permanent Researcher
2015
2020
Claire Amiable
PhD Student
2015
2020
Julie Paoletti
Research Engineer
2015
2020
Elise Salanouve
Undergraduate Student
2015
2020
Anne Noel
Undergraduate Student
2015
2020
Nicolas Wlodarczyk
Post-doc
2015
2020
Sandrine Guillou
Post-doc
2015
2020
Soizic Prado
Post-doc
2015
2020
Alex Cartier
Undergraduate Student
2015
2020
Luke Alvey
Post-doc
2015
2020
Olivier Nesme
Undergraduate Student
2015
2020
Nathalie Trawinski
Undergraduate Student
2015
2020
Thuy-Ha Dao
Undergraduate Student
2015
2020
Céline Taglang
Undergraduate Student
2015
2020
Laura Lanoe
Undergraduate Student
2015
2020
Valérie Toum
Undergraduate Student
2015
2020
Thomas Alexandre
PhD Student
2015
2020
Isabelle Salard-Arnaud
Post-doc
2015
2020
Alexandru Lupan
Post-doc
2015
2020
Edouard Seclaman
Post-doc
2015
2020
Laurene Vaupre
Undergraduate Student
2015
2020
Victor Penaud
Undergraduate Student
2015
2020
Khaled BENKALI
Undergraduate Student
2015
2020
Brice Murciano
Undergraduate Student
2015
2020
Dhenesh Puvanendran
Undergraduate Student
2015
2020
William Pauly-Batard
Undergraduate Student
2015
2020
Vincent Hervin
Research Engineer
2015
2020
Judith Souphron
Post-doc
2015
2020
Insaf Essadik
Undergraduate Student
2015
2020
Aurélie Bourderioux
Undergraduate Student
2015
2020
Loic Sanchez
Undergraduate Student
2015
2020
Steve Chiumento
Graduate Student
2015
2020
Chloe Seyrig
Undergraduate Student
2015
2020
Zakaria JEMOUAI
Graduate Student
2015
2020
Esteban Lobos
Undergraduate Student
2015
2020
Mélanie Montagna
Undergraduate Student
2015
2020
Karine Janowicz
Undergraduate Student
2015
2020
Racha Baatallah
Undergraduate Student
2015
2020
Violaine Baudu
Undergraduate Student
2015
2020
Eloi Coutant
PhD Student
2015
2020
Dylan Coelho
Undergraduate Student
2015
2020
Glwadys Gagnot
PhD Student
2015
2020
Patrick Walter
PhD Student
2015
2020
Amira TADROS
Undergraduate Student
2015
2020
Samy LEPREVOST
Undergraduate Student
2015
2020
Nitipol KEN SRIMONGKOLPITHAK
Visiting Scientist
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Contact

Phone: 33/1 40 61 38 05 Email: sylvie.pochet@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France