Sylvie Pochet

We are currently developing modified nucleos(t)ides as substrate mimics to provide insight into enzyme substrate recognition, as well as libraries of functionalized heterocycles useful for the fragment based approach. Novel enzymatic routes (transglycosylation, deamination, phosphorylation) as an alternative to chemical approaches are also considered. The synthesized molecules find applications in the identification of inhibitors of essential bacterial enzymes (TMPK from Mycobacterium tuberculosis, DNPH1, an N-hydrolase involved in cell proliferation, NAD kinases from Gram-positive bacteria). In addition, the new chemical entities implement the in house chemical libraries.